Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine

Birgit Simell; Anu Nurkka; Mika Lahdenkari; Noga Givon-Lavi; Helena Käyhty; Ron Dagan; Jukka Jokinena

doi:10.1128/CVI.05369-11

Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine

Birgit Simell
, Anu Nurkka
, Mika Lahdenkari
, Noga Givon-Lavi
, Helena Käyhty
, Ron Dagan
, Jukka Jokinena

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.

Original language	English
Pages (from-to)	96-99
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1128/CVI.05369-11
State	Published - Jan 2012
Externally published	Yes

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Simell, B., Nurkka, A., Lahdenkari, M., Givon-Lavi, N., Käyhty, H., Dagan, R., & Jokinena, J. (2012). Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine. Clinical and Vaccine Immunology, 19(1), 96-99. https://doi.org/10.1128/CVI.05369-11

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abstract = "Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.",

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Simell, B, Nurkka, A, Lahdenkari, M, Givon-Lavi, N, Käyhty, H, Dagan, R & Jokinena, J 2012, 'Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine', Clinical and Vaccine Immunology, vol. 19, no. 1, pp. 96-99. https://doi.org/10.1128/CVI.05369-11

Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine. / Simell, Birgit; Nurkka, Anu; Lahdenkari, Mika et al.
In: Clinical and Vaccine Immunology, Vol. 19, No. 1, 01.2012, p. 96-99.

Research output: Contribution to journal › Article › peer-review

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AU - Simell, Birgit

AU - Nurkka, Anu

AU - Lahdenkari, Mika

AU - Givon-Lavi, Noga

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AU - Dagan, Ron

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AB - Association of pneumococcal nasopharyngeal carriage with the concentration and opsonophagocytic activity (OPA) of serum serotype-specific antibodies was determined for toddlers 1 month after immunization with a 9-valent pneumococcal conjugate vaccine. Higher anti-serotype 14 and anti-serotype 19F IgG and anti-serotype 14 IgM correlated with a lowered probability of pneumococcal acquisition. Postvaccination OPA did not correlate with pneumococcal carriage.

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Association of serotype-specific antibody concentrations and functional antibody titers with subsequent pneumococcal carriage in toddlers immunized with a 9-valent pneumococcal conjugate vaccine

Abstract

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