Apnea induced by respiratory syncytial virus infection is not associated with viral invasion of the central nervous system

Daniella Levy Erez; Havatzelet Yarden-Bilavsky; Ella Mendelson; Yael Yuhas; Shai Ashkenazi; Elhanan Nahum; Eva Berent; Musa Hindiyeh; Efraim Bilavsky

doi:10.1097/INF.0000000000000311

Apnea induced by respiratory syncytial virus infection is not associated with viral invasion of the central nervous system

Daniella Levy Erez, Havatzelet Yarden-Bilavsky, Ella Mendelson, Yael Yuhas, Shai Ashkenazi, Elhanan Nahum, Eva Berent, Musa Hindiyeh, Efraim Bilavsky

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We aimed to study whether direct central nervous system invasion is responsible for the neurologic manifestations seen in hospitalized infants with respiratory syncytial virus (RSV) infection. Cerebrospinal fluid from infants with RSV infection was tested for the detection of the following respiratory RNA viruses: RSV, influenza A and B, pandemic influenza H1N1, Parainfluenza-3, human metapneumovirus, adenovirus, parechovirus and enterovirus. All children tested negative for the presence of viral material in the cerebrospinal fluid. Our results support the notion that the mechanism of RSV-induced neurologic manifestations, including apnea, is not direct central nervous system invasion.

Original language	English
Pages (from-to)	880-881
Number of pages	2
Journal	Pediatric Infectious Disease Journal
Volume	33
Issue number	8
DOIs	https://doi.org/10.1097/INF.0000000000000311
State	Published - Aug 2014
Externally published	Yes

Keywords

Apnea
Central nervous system
Cerebrospinal fluid
Respiratory syncytial virus

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10.1097/INF.0000000000000311

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abstract = "We aimed to study whether direct central nervous system invasion is responsible for the neurologic manifestations seen in hospitalized infants with respiratory syncytial virus (RSV) infection. Cerebrospinal fluid from infants with RSV infection was tested for the detection of the following respiratory RNA viruses: RSV, influenza A and B, pandemic influenza H1N1, Parainfluenza-3, human metapneumovirus, adenovirus, parechovirus and enterovirus. All children tested negative for the presence of viral material in the cerebrospinal fluid. Our results support the notion that the mechanism of RSV-induced neurologic manifestations, including apnea, is not direct central nervous system invasion.",

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AU - Erez, Daniella Levy

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AU - Mendelson, Ella

AU - Yuhas, Yael

AU - Ashkenazi, Shai

AU - Nahum, Elhanan

AU - Berent, Eva

AU - Hindiyeh, Musa

AU - Bilavsky, Efraim

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Apnea induced by respiratory syncytial virus infection is not associated with viral invasion of the central nervous system

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