Aplastic crisis due to human b19 parvovirus infection in red cell pyrimidine-5′ -nucleotidase deficiency

Gideon Rechavi; Ami Vonsover; Yossef Manor; Fernando Mileguir; Ofer Shpilberg; George Kende; Frida Brok-Simoni; Matilda Mandel; Tamar Gotlieb-Stematski; Isaac Ben-Bassat; Bracha Ramot

doi:10.1159/000205278

Aplastic crisis due to human b19 parvovirus infection in red cell pyrimidine-5′ -nucleotidase deficiency

Gideon Rechavi, Ami Vonsover, Yossef Manor, Fernando Mileguir, Ofer Shpilberg, George Kende, Frida Brok-Simoni, Matilda Mandel, Tamar Gotlieb-Stematski, Isaac Ben-Bassat, Bracha Ramot

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5′-nucleotidase (P-5′-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on theassociation of B19-HPV-related aplastic crisis with P-5′-N deficiency.

Original language	English
Pages (from-to)	46-49
Number of pages	4
Journal	Acta Haematologica
Volume	82
Issue number	1
DOIs	https://doi.org/10.1159/000205278
State	Published - 1989
Externally published	Yes

Keywords

Aplastic crisis
B19 parvovirus
Molecular hybridization
Pyrimidine-5′-nucleotidase deficiency

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10.1159/000205278

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title = "Aplastic crisis due to human b19 parvovirus infection in red cell pyrimidine-5′ -nucleotidase deficiency",

abstract = "Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5′-nucleotidase (P-5′-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on theassociation of B19-HPV-related aplastic crisis with P-5′-N deficiency.",

keywords = "Aplastic crisis, B19 parvovirus, Molecular hybridization, Pyrimidine-5′-nucleotidase deficiency",

author = "Gideon Rechavi and Ami Vonsover and Yossef Manor and Fernando Mileguir and Ofer Shpilberg and George Kende and Frida Brok-Simoni and Matilda Mandel and Tamar Gotlieb-Stematski and Isaac Ben-Bassat and Bracha Ramot",

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doi = "10.1159/000205278",

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T1 - Aplastic crisis due to human b19 parvovirus infection in red cell pyrimidine-5′ -nucleotidase deficiency

AU - Rechavi, Gideon

AU - Vonsover, Ami

AU - Manor, Yossef

AU - Mileguir, Fernando

AU - Shpilberg, Ofer

AU - Kende, George

AU - Brok-Simoni, Frida

AU - Mandel, Matilda

AU - Gotlieb-Stematski, Tamar

AU - Ben-Bassat, Isaac

AU - Ramot, Bracha

PY - 1989

Y1 - 1989

N2 - Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5′-nucleotidase (P-5′-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on theassociation of B19-HPV-related aplastic crisis with P-5′-N deficiency.

AB - Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5′-nucleotidase (P-5′-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on theassociation of B19-HPV-related aplastic crisis with P-5′-N deficiency.

KW - Aplastic crisis

KW - B19 parvovirus

KW - Molecular hybridization

KW - Pyrimidine-5′-nucleotidase deficiency

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Aplastic crisis due to human b19 parvovirus infection in red cell pyrimidine-5′ -nucleotidase deficiency

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Keywords

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