TY - JOUR
T1 - Anticoagulation with sodium warfarin in children
T2 - Effect of a loading regimen
AU - Doyle, J. J.
AU - Koren, G.
AU - Cheng, M. Y.
AU - Blanchette, V. S.
PY - 1988/12
Y1 - 1988/12
N2 - To assess dose requirements of warfarin in children, we analyzed retrospectively the treatment of 26 patients with the drug. Subsequently we treated 15 children, prospectively, with a regimen derived from our retrospective analysis (0.2 mg/kg/day for 2 days). In the retrospective analysis we found the prothrombin time (PT) at day 2 to correlate significantly with the dose given on day 0 (p<0.001) and with the cumulative dose on days 0 and 1 (p<0.001), but the standardized loading regimen resulted in a wide range of PTs independent of age, weight, or body surface area. The warfarin dose contributes only 40% of the variability in PT; an individual child's response to warfarin cannot be predicted accurately on the basis of the usual morphometric measurements.
AB - To assess dose requirements of warfarin in children, we analyzed retrospectively the treatment of 26 patients with the drug. Subsequently we treated 15 children, prospectively, with a regimen derived from our retrospective analysis (0.2 mg/kg/day for 2 days). In the retrospective analysis we found the prothrombin time (PT) at day 2 to correlate significantly with the dose given on day 0 (p<0.001) and with the cumulative dose on days 0 and 1 (p<0.001), but the standardized loading regimen resulted in a wide range of PTs independent of age, weight, or body surface area. The warfarin dose contributes only 40% of the variability in PT; an individual child's response to warfarin cannot be predicted accurately on the basis of the usual morphometric measurements.
UR - http://www.scopus.com/inward/record.url?scp=0024266067&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(88)80589-4
DO - 10.1016/S0022-3476(88)80589-4
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C2 - 3193316
AN - SCOPUS:0024266067
SN - 0022-3476
VL - 113
SP - 1095
EP - 1097
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 6
ER -