Antibacterial Activity of Rose Bengal Entrapped in Organically Modified Silica Matrices

Yanna Gurianov, Michael Meistelman, Yael Albo, Marina Nisnevitch, Faina Nakonechny

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Photosensitizers (PSs) are known as powerful antibacterial agents that are activated by direct exposure to visible light. PSs can be noncovalently entrapped into the silica gel network for their controlled release into a contaminated area. The immobilization of PS-containing gel matrices on a polymer support expands their possible applications, such as antibacterial surfaces and coatings, which can be used for the disinfection of liquids. In the current study, we report the use of Rose Bengal (RB) incorporated into organically modified silica matrices (RB@ORMOSIL matrices) by the sol-gel technique. The RB matrices exhibit high activity against Gram-positive and Gram-negative bacteria under illumination by white light. The amount and timing of solidifier addition to the matrix affected the interaction of the latter with the RB, which in turn could affect the antibacterial activity of RB. The most active specimen against both Gram-positive and Gram-negative bacterial cells was the RB6@ORMOSIL matrix immobilized on a linear low-density polyethylene surface, which was prepared by an easy, cost-effective, and simple thermal adhesion method. This specimen, RB6@OR@LLDPE, showed the low release of RB in an aqueous environment, and exhibited high long-term antibacterial activity in at least 14 rounds of recycled use against S. aureus and in 11 rounds against E. coli.

Original languageEnglish
Article number3716
JournalInternational Journal of Molecular Sciences
Issue number7
StatePublished - 1 Apr 2022


  • Rose Bengal
  • antibacterial surfaces
  • modified silica
  • photosensitizers
  • sol-gel


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