Anti-proliferative activity of the combination of salan Ti(IV) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: Synergism with cisplatin

Nitzan Ganot, Boris Redko, Gary Gellerman, Edit Y. Tshuva

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Two diaminobis(phenolato) Ti(iv) complexes were separately combined with azatoxin, camptothecin or cisplatin and underwent in vitro cytotoxicity analysis toward HT-29 and NCI-H1229 cancer cell lines. The methylated salan derivative exhibited synergistic effects with cisplatin at varying ratios toward both lines, when the compounds were administered fresh and simultaneously, implying great medicinal potential.

Original languageEnglish
Pages (from-to)7874-7879
Number of pages6
JournalRSC Advances
Volume5
Issue number11
DOIs
StatePublished - 2015

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