An outbreak of multiresistant Klebsiella in a neonatal intensive care unit

O. Reish, S. Ashkenazi, N. Naor, Z. Samra, P. Merlob

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


An outbreak of multiresistant Klebsiella pneumoniae occurring in a neonatal intensive care unit is described. All infections developed at least 5 days after admission to the unit (range, 5-40 days). Four infants had septicaemia and one had urinary tract infection. Three of the infected infants died. All klebsiella isolates were resistant to ampicillin, cefotaxime, cefuroxime, co-amoxiclav, mezlocillin, chloramphenicol, gentamicin, and ceftazidime (except in two); all were susceptible to imipenem, amikacin and quinolones. An extensive case-control study identified the following significant risk factors for colonization: prematurity; presence of indwelling catheters; previous antibiotic treatment; and parenteral nutrition. The outbreak was controlled with re-emphasis on strict handwashing practices, cohorting, closure of the unit to outborn admissions, and changing the regimen of empirical antibiotic therapy. Physicians should be aware of multiresistant Klebsiella spp. and change treatment whenever clinically indicated, even before culture results are available.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalJournal of Hospital Infection
Issue number4
StatePublished - Dec 1993
Externally publishedYes


  • Klebsiella pneumoniae
  • Multiresistance
  • antibiotics
  • indwelling catheter
  • total parenteral nutrition


Dive into the research topics of 'An outbreak of multiresistant Klebsiella in a neonatal intensive care unit'. Together they form a unique fingerprint.

Cite this