Amplified CPEs enhancement of chorioamnion membrane mass transport by encapsulation in nano-sized PLGA particles

Aharon Azagury, Eliz Amar-Lewis, Reut Appel, Mordechai Hallak, Joseph Kost

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Chemical penetration enhancers (CPEs) have long been used for mass transport enhancement across membranes. Many CPEs are used in a solution or gel and could be a solvent. The use of CPEs is mainly limited due to their toxicity/irritation levels. This study presents the evaluation of encapsulated CPEs in nano-sized polymeric particles on the chorioamnion (CA) membrane mass transport. CPEs’ mass encapsulated in nanoparticles was decreased by 10,000-fold. Interestingly, this approach resulted in a 6-fold increase in mass transport across the CA. This approach may also be used with other CPEs' base applications necessitating lower CPE concentration. Applying Ultrasound (US) has shown to increase the release rate of and also the mass transport across the CA membrane. It is proposed that encapsulated CPEs penetrate into the CA membrane thus prolonging their exposure, possibly extending their penetration into the CA membrane, while insonation also deepens their penetration into the CA membrane.

Original languageEnglish
Pages (from-to)292-299
Number of pages8
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume117
DOIs
StatePublished - 1 Aug 2017
Externally publishedYes

Keywords

  • Chemical penetration enhancers
  • Chorioamnion
  • Mass transport enhancement
  • Nanoparticles
  • PLGA
  • Ultrasound

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