Aminoisobutyric acid leads a fluorescent syn-bimane LASER probe across the blood-brain barrier

Inbal Lapidot; Danny Baranes; Albert Pinhasov; Gary Gellerman; Amnon Albeck; Flavio Grynszpan; Shimon E. Shatzmiller

doi:10.2174/1573406411666150518105010

Aminoisobutyric acid leads a fluorescent syn-bimane LASER probe across the blood-brain barrier

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6 Scopus citations

Abstract

Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.

Original language	English
Pages (from-to)	48-53
Number of pages	6
Journal	Medicinal Chemistry
Volume	12
Issue number	1
DOIs	https://doi.org/10.2174/1573406411666150518105010
State	Published - 1 Feb 2016

Keywords

Blood-brain barrier
Fluorescence microscopy
Fluorescent probe
Laser dye
Syn-bimane

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10.2174/1573406411666150518105010

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title = "Aminoisobutyric acid leads a fluorescent syn-bimane LASER probe across the blood-brain barrier",

abstract = "Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.",

keywords = "Blood-brain barrier, Fluorescence microscopy, Fluorescent probe, Laser dye, Syn-bimane",

author = "Inbal Lapidot and Danny Baranes and Albert Pinhasov and Gary Gellerman and Amnon Albeck and Flavio Grynszpan and Shatzmiller, \{Shimon E.\}",

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AU - Lapidot, Inbal

AU - Baranes, Danny

AU - Pinhasov, Albert

AU - Gellerman, Gary

AU - Albeck, Amnon

AU - Grynszpan, Flavio

AU - Shatzmiller, Shimon E.

PY - 2016/2/1

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KW - Blood-brain barrier

KW - Fluorescence microscopy

KW - Fluorescent probe

KW - Laser dye

KW - Syn-bimane

UR - https://www.scopus.com/pages/publications/84959449259

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Aminoisobutyric acid leads a fluorescent syn-bimane LASER probe across the blood-brain barrier

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