Adult infection with hepatitis A despite declining endemicity; in favor of adult vaccination

David Gillis; Itamar Grotto; Daniel Mimouni; Michael Huerta; Michael Gdalevich; Ofer Shpilberg

doi:10.1016/S0264-410X(02)00109-3

Adult infection with hepatitis A despite declining endemicity; in favor of adult vaccination

David Gillis, Itamar Grotto, Daniel Mimouni, Michael Huerta, Michael Gdalevich, Ofer Shpilberg

Research output: Contribution to journal › Article › peer-review

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Abstract

Seropositivity against hepatitis A was examined among 4806 standing army personnel (4497 males and 309 females) during 1998-1999. Each bi-annual birth cohort examined showed a decline in seropositivity compared to the previous one. When compared with a study performed in 1989, however, for each of the 1961-1962, 1963-1964, 1965-1966, 1967-1968 and 1969-1970 birth cohorts examined, the 1998-1999 study showed 5-15% higher seropositivity. This trend remained after controlling for differences between the two studies in ethnic origin, sibship size and level of education. The overall seroconversion rate is estimated as 1.15% per year and the clinical to subclinical ratio as 1:14. Thus, hepatitis A infection continues to occur in the young adult age group and vaccination of this group should be considered.

Original language	English
Pages (from-to)	2243-2248
Number of pages	6
Journal	Vaccine
Volume	20
Issue number	17-18
DOIs	https://doi.org/10.1016/S0264-410X(02)00109-3
State	Published - 22 May 2002
Externally published	Yes

Keywords

Birth cohort
Hepatitis A
Immunity
Seropositivity
Vaccination

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10.1016/S0264-410X(02)00109-3

Cite this

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title = "Adult infection with hepatitis A despite declining endemicity; in favor of adult vaccination",

abstract = "Seropositivity against hepatitis A was examined among 4806 standing army personnel (4497 males and 309 females) during 1998-1999. Each bi-annual birth cohort examined showed a decline in seropositivity compared to the previous one. When compared with a study performed in 1989, however, for each of the 1961-1962, 1963-1964, 1965-1966, 1967-1968 and 1969-1970 birth cohorts examined, the 1998-1999 study showed 5-15% higher seropositivity. This trend remained after controlling for differences between the two studies in ethnic origin, sibship size and level of education. The overall seroconversion rate is estimated as 1.15% per year and the clinical to subclinical ratio as 1:14. Thus, hepatitis A infection continues to occur in the young adult age group and vaccination of this group should be considered.",

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AU - Gillis, David

AU - Grotto, Itamar

AU - Mimouni, Daniel

AU - Huerta, Michael

AU - Gdalevich, Michael

AU - Shpilberg, Ofer

PY - 2002/5/22

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N2 - Seropositivity against hepatitis A was examined among 4806 standing army personnel (4497 males and 309 females) during 1998-1999. Each bi-annual birth cohort examined showed a decline in seropositivity compared to the previous one. When compared with a study performed in 1989, however, for each of the 1961-1962, 1963-1964, 1965-1966, 1967-1968 and 1969-1970 birth cohorts examined, the 1998-1999 study showed 5-15% higher seropositivity. This trend remained after controlling for differences between the two studies in ethnic origin, sibship size and level of education. The overall seroconversion rate is estimated as 1.15% per year and the clinical to subclinical ratio as 1:14. Thus, hepatitis A infection continues to occur in the young adult age group and vaccination of this group should be considered.

AB - Seropositivity against hepatitis A was examined among 4806 standing army personnel (4497 males and 309 females) during 1998-1999. Each bi-annual birth cohort examined showed a decline in seropositivity compared to the previous one. When compared with a study performed in 1989, however, for each of the 1961-1962, 1963-1964, 1965-1966, 1967-1968 and 1969-1970 birth cohorts examined, the 1998-1999 study showed 5-15% higher seropositivity. This trend remained after controlling for differences between the two studies in ethnic origin, sibship size and level of education. The overall seroconversion rate is estimated as 1.15% per year and the clinical to subclinical ratio as 1:14. Thus, hepatitis A infection continues to occur in the young adult age group and vaccination of this group should be considered.

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KW - Hepatitis A

KW - Immunity

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KW - Vaccination

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Adult infection with hepatitis A despite declining endemicity; in favor of adult vaccination

Abstract

Keywords

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