TY - JOUR
T1 - Acute myocardial infarction - the angiographic picture
T2 - new insights into the pathogenesis of myocardial infarction
AU - Rozenman, Y.
AU - Rosenheck, S.
AU - Nassar, H.
AU - Welber, S.
AU - Sapoznikov, D.
AU - Lotan, C.
AU - Mosseri, M.
AU - Weiss, A. T.
AU - Gotsman, M. S.
N1 - Funding Information:
1>This research was supported by a grant from the National Council for Research and Development, Israel and GSF Munchen, Germany.
PY - 1995
Y1 - 1995
N2 - The angiographic appearance of the coronary arteries were examined in 302 patients with stable angina pectoris and compared to 308 patients with acute myocardial infarction, who received high-dose intravenous thrombolytic therapy, in order to elucidate the underlying angiopathological picture in the two diseases. In each group coronary lesions were present in proximal segments of the arteries and were closely related to bifurcations. Lesions were more extensively distributed in the coronary tree in patients with stable angina and they had an average of 5.4 lesions per patient, compared to the acute myocardial infarction group who had only 2.4 lesions. Also, in the acute myocardial infarction patients, four-fifths of the culprit arteries were patent, 104 (34%) had a ruptured plaque, 22 (7%) had an ulcerated plaque and in 190 (62%) the lesions were eccentric. The study shows that patients with myocardial infarction who are suitable for thrombolysis have a unique coronary angiographic picture and the acute episode is caused by sudden rupture of a localized atheromatous plaque which initiates an obstructive thrombotic cascade.
AB - The angiographic appearance of the coronary arteries were examined in 302 patients with stable angina pectoris and compared to 308 patients with acute myocardial infarction, who received high-dose intravenous thrombolytic therapy, in order to elucidate the underlying angiopathological picture in the two diseases. In each group coronary lesions were present in proximal segments of the arteries and were closely related to bifurcations. Lesions were more extensively distributed in the coronary tree in patients with stable angina and they had an average of 5.4 lesions per patient, compared to the acute myocardial infarction group who had only 2.4 lesions. Also, in the acute myocardial infarction patients, four-fifths of the culprit arteries were patent, 104 (34%) had a ruptured plaque, 22 (7%) had an ulcerated plaque and in 190 (62%) the lesions were eccentric. The study shows that patients with myocardial infarction who are suitable for thrombolysis have a unique coronary angiographic picture and the acute episode is caused by sudden rupture of a localized atheromatous plaque which initiates an obstructive thrombotic cascade.
KW - Plaque
KW - Rupture
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=0029128590&partnerID=8YFLogxK
U2 - 10.1016/0167-5273(95)02333-R
DO - 10.1016/0167-5273(95)02333-R
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C2 - 7591311
AN - SCOPUS:0029128590
SN - 0167-5273
VL - 49
SP - S11-S16
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -