Activation of insulin signaling by botanical products

Tovit Rosenzweig, Sanford R. Sampson

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Type 2 diabetes (T2D) is a worldwide health problem, ranked as one of the leading causes for severe morbidity and premature mortality in modern society. Management of blood glucose is of major importance in order to limit the severe outcomes of the disease. However, despite the impressive success in the development of new antidiabetic drugs, almost no progress has been achieved with regard to the development of novel insulin-sensitizing agents. As insulin resistance is the most eminent factor in the patho-etiology of T2D, it is not surprising that an alarming number of patients still fail to meet glycemic goals. Owing to its wealth of chemical structures, the plant kingdom is considered as an inventory of compounds exerting various bioactivities, which might be used as a basis for the development of novel medications for various pathologies. Antidiabetic activity is found in over 400 plant species, and is attributable to varying mechanisms of action. Nevertheless, relatively limited evidence exists regarding phytochemicals directly activating insulin signaling, which is the focus of this review. Here, we will list plants and phytochemicals that have been found to improve insulin sensitivity by activation of the insulin signaling cascade, and will describe the active constituents and their mechanism of action.

Original languageEnglish
Article number4193
JournalInternational Journal of Molecular Sciences
Issue number8
StatePublished - 2 Apr 2021


  • GLUT4
  • Insulin receptor
  • Insulin signaling
  • Medicinal plants
  • PTP1B
  • Phytochemicals
  • Type 2 diabetes


Dive into the research topics of 'Activation of insulin signaling by botanical products'. Together they form a unique fingerprint.

Cite this