Accumulation of cocaine in maternal and fetal hair; The dose response curve

Rachel Forman; Joyce Schneiderman; Julia Klein; Karen Graham; Mark Greenwald; Gideon Koren

doi:10.1016/0024-3205(92)90284-V

Accumulation of cocaine in maternal and fetal hair; The dose response curve

Rachel Forman, Joyce Schneiderman, Julia Klein, Karen Graham, Mark Greenwald, Gideon Koren

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Cocaine and its major metabolites are incorporated into hair during the growth of the shaft and stay there for the whole life of the hair. Cocaine crosses the placenta and its metabolites for example Benzoylecgonine (BZ), have been found in neonatal urine, meconium and hair. In order to utilize hair measurements of cocaine as a biological marker of systemic exposure, we conducted both animal and human investigations on the dose response characteristics of this phenomenon. Ourdata suggest that both maternal and fetal accumulation of cocaine and its metabolite follow a linear pattern within the clinically used doses. Similarly, a good correlation was observed in animals between maternal dose and fetal hair accumulation.

Original language	English
Pages (from-to)	1333-1341
Number of pages	9
Journal	Life Sciences
Volume	50
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(92)90284-V
State	Published - 1992
Externally published	Yes

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title = "Accumulation of cocaine in maternal and fetal hair; The dose response curve",

abstract = "Cocaine and its major metabolites are incorporated into hair during the growth of the shaft and stay there for the whole life of the hair. Cocaine crosses the placenta and its metabolites for example Benzoylecgonine (BZ), have been found in neonatal urine, meconium and hair. In order to utilize hair measurements of cocaine as a biological marker of systemic exposure, we conducted both animal and human investigations on the dose response characteristics of this phenomenon. Ourdata suggest that both maternal and fetal accumulation of cocaine and its metabolite follow a linear pattern within the clinically used doses. Similarly, a good correlation was observed in animals between maternal dose and fetal hair accumulation.",

author = "Rachel Forman and Joyce Schneiderman and Julia Klein and Karen Graham and Mark Greenwald and Gideon Koren",

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doi = "10.1016/0024-3205(92)90284-V",

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T1 - Accumulation of cocaine in maternal and fetal hair; The dose response curve

AU - Forman, Rachel

AU - Schneiderman, Joyce

AU - Klein, Julia

AU - Graham, Karen

AU - Greenwald, Mark

AU - Koren, Gideon

N1 - Funding Information: Supported by grants of Physicians Services Inc, Toronto, Dept. of Health and Welfare Canada, and Medical Research Council of Canada,

PY - 1992

Y1 - 1992

N2 - Cocaine and its major metabolites are incorporated into hair during the growth of the shaft and stay there for the whole life of the hair. Cocaine crosses the placenta and its metabolites for example Benzoylecgonine (BZ), have been found in neonatal urine, meconium and hair. In order to utilize hair measurements of cocaine as a biological marker of systemic exposure, we conducted both animal and human investigations on the dose response characteristics of this phenomenon. Ourdata suggest that both maternal and fetal accumulation of cocaine and its metabolite follow a linear pattern within the clinically used doses. Similarly, a good correlation was observed in animals between maternal dose and fetal hair accumulation.

AB - Cocaine and its major metabolites are incorporated into hair during the growth of the shaft and stay there for the whole life of the hair. Cocaine crosses the placenta and its metabolites for example Benzoylecgonine (BZ), have been found in neonatal urine, meconium and hair. In order to utilize hair measurements of cocaine as a biological marker of systemic exposure, we conducted both animal and human investigations on the dose response characteristics of this phenomenon. Ourdata suggest that both maternal and fetal accumulation of cocaine and its metabolite follow a linear pattern within the clinically used doses. Similarly, a good correlation was observed in animals between maternal dose and fetal hair accumulation.

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Accumulation of cocaine in maternal and fetal hair; The dose response curve

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