ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

Jan Damoiseaux; Arad Dotan; Marvin J. Fritzler; Dimitrios P. Bogdanos; Pier Luigi Meroni; Dirk Roggenbuck; Michel Goldman; Nils Landegren; Paul Bastard; Yehuda Shoenfeld; Karsten Conrad

doi:10.1016/j.autrev.2021.103012

ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

Jan Damoiseaux
, Arad Dotan
, Marvin J. Fritzler
, Dimitrios P. Bogdanos
, Pier Luigi Meroni
, Dirk Roggenbuck
, Michel Goldman
, Nils Landegren
, Paul Bastard
, Yehuda Shoenfeld
, Karsten Conrad

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.

Original language	English
Article number	103012
Journal	Autoimmunity Reviews
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.autrev.2021.103012
State	Published - 1 Mar 2022
Externally published	Yes

Keywords

SARS-CoV-2
Autoantibodies
COVID-19
Autoimmunity
Molecular mimicry
MIS-C
Antiphospholipid syndrome
Anti-IFNa

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Damoiseaux, J., Dotan, A., Fritzler, M. J., Bogdanos, D. P., Meroni, P. L., Roggenbuck, D., Goldman, M., Landegren, N., Bastard, P., Shoenfeld, Y., & Conrad, K. (2022). ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. Autoimmunity Reviews, 21(3), Article 103012. https://doi.org/10.1016/j.autrev.2021.103012

Damoiseaux, Jan ; Dotan, Arad ; Fritzler, Marvin J. et al. / ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. In: Autoimmunity Reviews. 2022 ; Vol. 21, No. 3.

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title = "ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies",

abstract = "The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.",

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Damoiseaux, J, Dotan, A, Fritzler, MJ, Bogdanos, DP, Meroni, PL, Roggenbuck, D, Goldman, M, Landegren, N, Bastard, P, Shoenfeld, Y & Conrad, K 2022, 'ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies', Autoimmunity Reviews, vol. 21, no. 3, 103012. https://doi.org/10.1016/j.autrev.2021.103012

ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. / Damoiseaux, Jan; Dotan, Arad; Fritzler, Marvin J. et al.
In: Autoimmunity Reviews, Vol. 21, No. 3, 103012, 01.03.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.

T2 - The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

AU - Damoiseaux, Jan

AU - Dotan, Arad

AU - Fritzler, Marvin J.

AU - Bogdanos, Dimitrios P.

AU - Meroni, Pier Luigi

AU - Roggenbuck, Dirk

AU - Goldman, Michel

AU - Landegren, Nils

AU - Bastard, Paul

AU - Shoenfeld, Yehuda

AU - Conrad, Karsten

PY - 2022/3/1

Y1 - 2022/3/1

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AB - The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.

KW - SARS-CoV-2

KW - Autoantibodies

KW - COVID-19

KW - Autoimmunity

KW - Molecular mimicry

KW - MIS-C

KW - Antiphospholipid syndrome

KW - Anti-IFNa

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DO - 10.1016/j.autrev.2021.103012

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SN - 1568-9972

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Damoiseaux J, Dotan A, Fritzler MJ, Bogdanos DP, Meroni PL, Roggenbuck D et al. ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. Autoimmunity Reviews. 2022 Mar 1;21(3):103012. doi: 10.1016/j.autrev.2021.103012

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