ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

Jan Damoiseaux; Arad Dotan; Marvin J. Fritzler; Dimitrios P. Bogdanos; Pier Luigi Meroni; Dirk Roggenbuck; Michel Goldman; Nils Landegren; Paul Bastard; Yehuda Shoenfeld; Karsten Conrad

doi:10.1016/j.autrev.2021.103012

ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies

Jan Damoiseaux, Arad Dotan, Marvin J. Fritzler, Dimitrios P. Bogdanos, Pier Luigi Meroni, Dirk Roggenbuck, Michel Goldman, Nils Landegren, Paul Bastard, Yehuda Shoenfeld, Karsten Conrad

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Abstract

The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.

Original language	English
Article number	103012
Journal	Autoimmunity Reviews
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.autrev.2021.103012
State	Published - 1 Mar 2022
Externally published	Yes

Keywords

SARS-CoV-2
Autoantibodies
COVID-19
Autoimmunity
Molecular mimicry
MIS-C
Antiphospholipid syndrome
Anti-IFNa

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Damoiseaux, J., Dotan, A., Fritzler, M. J., Bogdanos, D. P., Meroni, P. L., Roggenbuck, D., Goldman, M., Landegren, N., Bastard, P., Shoenfeld, Y., & Conrad, K. (2022). ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. Autoimmunity Reviews, 21(3), Article 103012. https://doi.org/10.1016/j.autrev.2021.103012

Damoiseaux, Jan ; Dotan, Arad ; Fritzler, Marvin J. et al. / ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. In: Autoimmunity Reviews. 2022 ; Vol. 21, No. 3.

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abstract = "The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Symposium on Autoantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.",

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author = "Jan Damoiseaux and Arad Dotan and Fritzler, {Marvin J.} and Bogdanos, {Dimitrios P.} and Meroni, {Pier Luigi} and Dirk Roggenbuck and Michel Goldman and Nils Landegren and Paul Bastard and Yehuda Shoenfeld and Karsten Conrad",

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Damoiseaux, J, Dotan, A, Fritzler, MJ, Bogdanos, DP, Meroni, PL, Roggenbuck, D, Goldman, M, Landegren, N, Bastard, P, Shoenfeld, Y & Conrad, K 2022, 'ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies', Autoimmunity Reviews, vol. 21, no. 3, 103012. https://doi.org/10.1016/j.autrev.2021.103012

ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. / Damoiseaux, Jan; Dotan, Arad; Fritzler, Marvin J. et al.
In: Autoimmunity Reviews, Vol. 21, No. 3, 103012, 01.03.2022.

Research output: Contribution to journal › Article › peer-review

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T1 - ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting.

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AU - Dotan, Arad

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AU - Bogdanos, Dimitrios P.

AU - Meroni, Pier Luigi

AU - Roggenbuck, Dirk

AU - Goldman, Michel

AU - Landegren, Nils

AU - Bastard, Paul

AU - Shoenfeld, Yehuda

AU - Conrad, Karsten

PY - 2022/3/1

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Damoiseaux J, Dotan A, Fritzler MJ, Bogdanos DP, Meroni PL, Roggenbuck D et al. ABSTRACT The relation between infections and autoimmune diseases has been extensively investigated. Multiple studies suggest a causal relation between these two entities with molecular mimicry, hyperstimulation and dysregulation of the immune system as plausible mechanisms. The recent pandemic with a new virus, i.e., SARS-CoV-2, has resulted in numerous studies addressing the potential of this virus to induce autoimmunity and, eventually, autoimmune disease. In addition, it has also revealed that pre-existing auto-immunity (auto-Abs neutralizing type I IFNs) could cause life-threatening disease. Therefore, the topic of the 15th Dresden Sympo toantibodies was focused on autoimmunity in the SARS-CoV-2 era. This report is a collection and distillation of the topics presented at this meeting. The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies. Autoimmunity Reviews. 2022 Mar 1;21(3):103012. doi: 10.1016/j.autrev.2021.103012

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