A prevalent Y;15 translocation in the ethiopian beta Israel community in Israel

R. Chen-Shtoyerman; S. Josefsberg Ben-Yehoshua; R. Nissani; J. Rosensaft; Z. Appelman

doi:10.1159/000336201

A prevalent Y;15 translocation in the ethiopian beta Israel community in Israel

R. Chen-Shtoyerman, S. Josefsberg Ben-Yehoshua, R. Nissani, J. Rosensaft, Z. Appelman

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We describe 7 cases of abnormal karyotypes involving chromosomes Y and 15 in Ethiopian Beta Israel patients: 46,XX, der(15)t(Y;15)(q12;p12) and 46,XY,der(15)t(Y;15)(q12;p12). Six cases were incidentally found in amniocentesis performed for various indications; the indication for karyotyping in 1 case was recurrent abortions. To the best of our knowledge, this is the first report of this translocation in a specific ethnic group. We conclude that the derivative chromosome 15 with chromosome Y is probably a normal variant in Ethiopian Beta Israel occurring at an estimated frequency of 4/74 (5.4%). The prenatal diagnosis of this translocation in this population probably does not require further parental testing.

Original language	English
Pages (from-to)	171-174
Number of pages	4
Journal	Cytogenetic and Genome Research
Volume	136
Issue number	3
DOIs	https://doi.org/10.1159/000336201
State	Published - Apr 2012
Externally published	Yes

Keywords

Beta Israel
Ethiopian Jews
Fluorescence in situ hybridization
Prenatal diagnosis
Y;15 translocation

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10.1159/000336201

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title = "A prevalent Y;15 translocation in the ethiopian beta Israel community in Israel",

abstract = "We describe 7 cases of abnormal karyotypes involving chromosomes Y and 15 in Ethiopian Beta Israel patients: 46,XX, der(15)t(Y;15)(q12;p12) and 46,XY,der(15)t(Y;15)(q12;p12). Six cases were incidentally found in amniocentesis performed for various indications; the indication for karyotyping in 1 case was recurrent abortions. To the best of our knowledge, this is the first report of this translocation in a specific ethnic group. We conclude that the derivative chromosome 15 with chromosome Y is probably a normal variant in Ethiopian Beta Israel occurring at an estimated frequency of 4/74 (5.4\%). The prenatal diagnosis of this translocation in this population probably does not require further parental testing.",

keywords = "Beta Israel, Ethiopian Jews, Fluorescence in situ hybridization, Prenatal diagnosis, Y;15 translocation",

author = "R. Chen-Shtoyerman and \{Josefsberg Ben-Yehoshua\}, S. and R. Nissani and J. Rosensaft and Z. Appelman",

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AU - Nissani, R.

AU - Rosensaft, J.

AU - Appelman, Z.

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AB - We describe 7 cases of abnormal karyotypes involving chromosomes Y and 15 in Ethiopian Beta Israel patients: 46,XX, der(15)t(Y;15)(q12;p12) and 46,XY,der(15)t(Y;15)(q12;p12). Six cases were incidentally found in amniocentesis performed for various indications; the indication for karyotyping in 1 case was recurrent abortions. To the best of our knowledge, this is the first report of this translocation in a specific ethnic group. We conclude that the derivative chromosome 15 with chromosome Y is probably a normal variant in Ethiopian Beta Israel occurring at an estimated frequency of 4/74 (5.4%). The prenatal diagnosis of this translocation in this population probably does not require further parental testing.

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KW - Ethiopian Jews

KW - Fluorescence in situ hybridization

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A prevalent Y;15 translocation in the ethiopian beta Israel community in Israel

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