TY - JOUR
T1 - A novel VIP responsive gene
T2 - Activity dependent neuroprotective protein
AU - Gozes, I.
AU - Zamostiano, R.
AU - Pinhasov, A.
AU - Bassan, M.
AU - Giladi, E.
AU - Steingart, R. A.
AU - Brenneman, D. E.
PY - 2000
Y1 - 2000
N2 - Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.
AB - Activity dependent neuroprotective protein (ADNP, 828 amino acids, pI 5.99) is a glial-derived protein that contains a femtomolar active neuroprotective peptide, NAPVSIPQ (NAP). VIP induces a two- to threefold increase in ADNP mRNA in astrocytes, suggesting that ADNP is a VIP-responsive gene. ADNP is widely distributed in the mouse hippocampus, cerebellum, and cerebral cortex. VIP has been shown to possess neuroprotective activity that may be exerted through the activation of glial proteins. We suggest that ADNP may be part of the VIP protection pathway through the femtomolaracting NAP and through putative interaction with other macromolecules.
UR - http://www.scopus.com/inward/record.url?scp=0034508629&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2000.tb06957.x
DO - 10.1111/j.1749-6632.2000.tb06957.x
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C2 - 11193814
AN - SCOPUS:0034508629
SN - 0077-8923
VL - 921
SP - 115
EP - 118
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -