A new diagnostic tool based on diffusion reflection measurements of gold nanoparticles

Rinat Ankri, Hamootal Duadi, Dror Fixler

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

The ability to quantitatively and non-invasively detect nanoparticles in tissues has important implications on their development as an in-vivo cancer diagnostic tool. The Diffusion Reflection (DR) method is a simple, non-invasive imaging technique which has been proven useful for the investigation of tissue's optical parameters. We present a new method for the measurements of the GNR concentration in tissue-like phantoms based on DR measurements and the intense light absorption of gold nanorods (GNR). Monte Carlo simulations and tissue-like phantom measurements of the reflected light intensity are presented. The ability to extract the phantoms' optical properties and the GNR concentration in it from DR measurements was demonstrated.

Original languageEnglish
Title of host publicationImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X
DOIs
StatePublished - 2012
Externally publishedYes
EventImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X - San Francisco, CA, United States
Duration: 21 Jan 201223 Jan 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8225
ISSN (Print)1605-7422

Conference

ConferenceImaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X
Country/TerritoryUnited States
CitySan Francisco, CA
Period21/01/1223/01/12

Keywords

  • Diffusion Reflection
  • Gold Nanorods
  • Monte-Carlo Simulations
  • Tissue-like Phantoms

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