A green bromination method for the synthesis of benzylic dibromides

Bhasker Radaram, Mindy Levine

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Reported herein is the identification of a new methodology for the dibromination of benzylic diols. This method proceeds in moderate to good yields for a wide variety of electron-deficient, electron-neutral, and electron-rich aromatic substrates. Moreover, the reagent, 1,3-dibromo-5,5-dimethylhydantoin, and the solvent, tetrahydrofuran, are substantially more environmentally benign than traditional solvents and reagents used for bromination. The utility of this methodology was demonstrated in the high-yielding synthesis of a key intermediate in the synthesis of omeprazole.

Original languageEnglish
Pages (from-to)4905-4908
Number of pages4
JournalTetrahedron Letters
Issue number35
StatePublished - 27 Aug 2014
Externally publishedYes


  • Benzylic alcohols
  • Bromination
  • Green chemistry
  • Tetrahydrofuran


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