TY - JOUR
T1 - A cluster of invasive meningococcal disease revealed by the characterization of a novel serogroup B meningococcal clone
AU - Valinsky, L.
AU - Jaffe, J.
AU - Keller, N.
AU - Block, C.
AU - Abramson, N.
AU - Stein-Zamir, C.
N1 - Publisher Copyright:
© Cambridge University Press 2015.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The incidence of invasive infections due to Neisseria meningitidis in Israel is about 1/100 000 population annually. Three cases of meningococcal meningitis were reported in employees at a single plant; the first case appeared in March 2013 and the second and third cases appeared in December, almost 9 months later. N. meningitidis serogroup B was isolated from cerebrospinal fluid samples. Multilocus sequence typing assigned the three meningococcal isolates to ST10418, a new sequence type and a member of the ST32 clonal complex. The clonality was confirmed by performance of pulsed-field gel electrophoresis. Post-exposure antibiotic prophylaxis was administered to close contacts of the first case. Upon the diagnosis of the additional two cases, post-exposure prophylaxis was administered to all the plant employees. This report demonstrates the importance of combining public health measures and advanced laboratory studies to confirm clonality and to prevent further disease spread in a closed setting.
AB - The incidence of invasive infections due to Neisseria meningitidis in Israel is about 1/100 000 population annually. Three cases of meningococcal meningitis were reported in employees at a single plant; the first case appeared in March 2013 and the second and third cases appeared in December, almost 9 months later. N. meningitidis serogroup B was isolated from cerebrospinal fluid samples. Multilocus sequence typing assigned the three meningococcal isolates to ST10418, a new sequence type and a member of the ST32 clonal complex. The clonality was confirmed by performance of pulsed-field gel electrophoresis. Post-exposure antibiotic prophylaxis was administered to close contacts of the first case. Upon the diagnosis of the additional two cases, post-exposure prophylaxis was administered to all the plant employees. This report demonstrates the importance of combining public health measures and advanced laboratory studies to confirm clonality and to prevent further disease spread in a closed setting.
KW - Cluster
KW - Neisseria meningitidis
KW - invasive meningococcal disease
KW - molecular epidemiology
UR - http://www.scopus.com/inward/record.url?scp=84983113643&partnerID=8YFLogxK
U2 - 10.1017/S0950268815001296
DO - 10.1017/S0950268815001296
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C2 - 26113514
AN - SCOPUS:84983113643
SN - 0950-2688
VL - 144
SP - 183
EP - 188
JO - Epidemiology and Infection
JF - Epidemiology and Infection
IS - 1
ER -