1,4-Dihydropyridine Cationic Peptidomimetics with Antibacterial Activity

Inbal Lapidot, Amnon Albeck, Gary Gellerman, Shimon Shatzmiller, Flavio Grynszpan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We synthesized new broad spectrum antibacterial cationic peptidomimetics centered on a hydrophobic 1,4-dihydropyridine (1,4-DHP) scaffold. The synthesis involves the preparation of the scaffold in a three step Hantzsch reaction followed by simultaneous coupling of the 1,4-DHP scaffold to two dipeptides bearing cationic side chains. The synthesized peptidomimetics were found to have no measurable toxic hemolytic effect against mammalian red blood cells. The compounds were found to have antibacterial activity against Gram-(-) and Gram-(+) bacteria with MICs in the range of 35-100 μg/mL. These cationic antimicrobial peptidomimetics will lead to more effective antibacterial drug candidates based on a synthetically accessible scaffold.

Original languageEnglish
Pages (from-to)243-247
Number of pages5
JournalInternational Journal of Peptide Research and Therapeutics
Issue number3
StatePublished - 27 Sep 2015


  • 1, 4-dihydropyridine scaffold
  • Anti-microbial
  • Broad spectrum anti-bacterial
  • Cationic peptides
  • Drug design
  • Peptidomimetics


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