Abstract
The 2-chloro-2-methylpropanoic ester serves as a steering group in the Schmidt glycosidation reaction. Rapid and efficient glycosidation of a range of sterically hindered alcohols takes place under mild, acidic conditions to afford the glycoside products in high yield and β-selectivity and without formation of orthoester side products. The 2-chloro-2-methylpropanoic ester is readily cleaved under mild, basic conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 1305-1307 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| State | Published - 19 Mar 2009 |
| Externally published | Yes |