Towards rational chemosensor design through improved understanding of experimental parameter variation and tolerance in cyclodextrin-promoted fluorescence detection

Dana J. DiScenza, Ella Culton, Molly Verderame, Julie Lynch, Nicole Serio, Mindy Levine

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

7 اقتباسات (Scopus)

ملخص

We have previously developed a highly efficient fluorescence-based toxicant-detection method that operates in complex environments to detect aromatic toxicants and toxicant metabolites with high sensitivity and selectivity. This method relies on the ability of γ-cyclodextrin to act as a supramolecular scaffold, and uses a variety of non-covalent interactions between the cyclodextrin, toxicant, and fluorophore to enable efficient detection. Reported herein is an investigation of the effect of various experimental parameters, including host concentration, temperature, pH, salt, and solvent, on the observed energy-transfer efficiencies. These results advance our understanding of γ-cyclodextrin-based association complexes and provide crucial information for the development of fluorescence-based sensors using such complexation and the resultant fluorescence-based detection.

اللغة الأصليةالإنجليزيّة
رقم المقال34
دوريةChemosensors
مستوى الصوت5
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 1 ديسمبر 2017
منشور خارجيًانعم

بصمة

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