The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype

Keyphrases

• Aging 14%
• Cell Senescence 14%
• Cells in Culture 14%
• DNA Damage 100%
• DNA Damage Signaling 14%
• Fibroblasts 14%
• Heat Shock Factor 1 (HSF1) 100%
• Heat Shock Response 71%
• NF-B 14%
• Nuclear factor-κB 14%
• Overexpression 14%
• Positive Feedback Regulation 14%
• Premature Senescence 14%
• Proteotoxic Stress 14%
• Replicative Senescence 14%
• Response Suppression 28%
• Senescence 100%
• Senescence Phenotype 100%
• Signaling Pathway 14%
• Sirtuin 1 (SIRT1) 14%
• Skin Fibroblasts 14%
• Translation Regulator 14%
• Werner Syndrome 14%

Biochemistry, Genetics and Molecular Biology

• DNA Damage 100%
• DNA Damage Response 20%
• Downregulation 40%
• Fibroblast 40%
• Heat Shock Factor 100%
• Heat Shock Response 100%
• P21 20%
• P53 20%
• Positive Feedback 20%
• Sirtuin1 20%
• Transcription 20%
• Werner Syndrome 20%