The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

Anna Chuprin; Ayelet Avin; Yael Goldfarb; Yonatan Herzig; Ben Levi; Adi Jacob; Asaf Sela; Shir Katz; Moran Grossman; Clotilde Guyon; Moran Rathaus; Haim Y. Cohen; Irit Sagi; Matthieu Giraud; Michael W. McBurney; Eystein S. Husebye; Jakub Abramson

doi:10.1038/ni.3194

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

Anna Chuprin, Ayelet Avin, Yael Goldfarb, Yonatan Herzig, Ben Levi, Adi Jacob, Asaf Sela, Shir Katz, Moran Grossman, Clotilde Guyon, Moran Rathaus, Haim Y. Cohen, Irit Sagi, Matthieu Giraud, Michael W. McBurney, Eystein S. Husebye, Jakub Abramson

نتاج البحث: نشر في مجلة › مقالة › مراجعة النظراء

69 اقتباسات (Scopus)

ملخص

Aire is a transcriptional regulator that induces the promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for the induction of immunological self-tolerance. Studies have offered molecular insights into how Aire operates, but more comprehensive understanding of this process still remains elusive. Here we found abundant expression of the protein deacetylase Sirtuin-1 (Sirt1) in mature Aire + mTECs, wherein it was required for the expression of Aire-dependent TRA-encoding genes and the subsequent induction of immunological self-tolerance. Our study elucidates a previously unknown molecular mechanism for Aire-mediated transcriptional regulation and identifies a unique function for Sirt1 in preventing organ-specific autoimmunity.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	737-745
عدد الصفحات	9
دورية	Nature Immunology
مستوى الصوت	16
رقم الإصدار	7
المعرِّفات الرقمية للأشياء	https://doi.org/10.1038/ni.3194
حالة النشر	نُشِر - 20 يوليو 2015
منشور خارجيًا	نعم

الوصول إلى المستند

10.1038/ni.3194

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

Chuprin, A., Avin, A., Goldfarb, Y., Herzig, Y., Levi, B., Jacob, A., Sela, A., Katz, S., Grossman, M., Guyon, C., Rathaus, M., Cohen, H. Y., Sagi, I., Giraud, M., McBurney, M. W., Husebye, E. S., & Abramson, J. (2015). The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance. Nature Immunology, 16(7), 737-745. https://doi.org/10.1038/ni.3194

@article{6f882ddfd4ce4686b9a44539770a345e,

title = "The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance",

abstract = "Aire is a transcriptional regulator that induces the promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for the induction of immunological self-tolerance. Studies have offered molecular insights into how Aire operates, but more comprehensive understanding of this process still remains elusive. Here we found abundant expression of the protein deacetylase Sirtuin-1 (Sirt1) in mature Aire + mTECs, wherein it was required for the expression of Aire-dependent TRA-encoding genes and the subsequent induction of immunological self-tolerance. Our study elucidates a previously unknown molecular mechanism for Aire-mediated transcriptional regulation and identifies a unique function for Sirt1 in preventing organ-specific autoimmunity.",

author = "Anna Chuprin and Ayelet Avin and Yael Goldfarb and Yonatan Herzig and Ben Levi and Adi Jacob and Asaf Sela and Shir Katz and Moran Grossman and Clotilde Guyon and Moran Rathaus and Cohen, {Haim Y.} and Irit Sagi and Matthieu Giraud and McBurney, {Michael W.} and Husebye, {Eystein S.} and Jakub Abramson",

year = "2015",

month = jul,

day = "20",

doi = "10.1038/ni.3194",

language = "אנגלית",

volume = "16",

pages = "737--745",

journal = "Nature Immunology",

issn = "1529-2908",

publisher = "Nature Publishing Group",

number = "7",

}

Chuprin, A, Avin, A, Goldfarb, Y, Herzig, Y, Levi, B, Jacob, A, Sela, A, Katz, S, Grossman, M, Guyon, C, Rathaus, M, Cohen, HY, Sagi, I, Giraud, M, McBurney, MW, Husebye, ES & Abramson, J 2015, 'The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance', Nature Immunology, المجلد 16, رقم 7, الصفحات 737-745. https://doi.org/10.1038/ni.3194

TY - JOUR

T1 - The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

AU - Chuprin, Anna

AU - Avin, Ayelet

AU - Goldfarb, Yael

AU - Herzig, Yonatan

AU - Levi, Ben

AU - Jacob, Adi

AU - Sela, Asaf

AU - Katz, Shir

AU - Grossman, Moran

AU - Guyon, Clotilde

AU - Rathaus, Moran

AU - Cohen, Haim Y.

AU - Sagi, Irit

AU - Giraud, Matthieu

AU - McBurney, Michael W.

AU - Husebye, Eystein S.

AU - Abramson, Jakub

PY - 2015/7/20

Y1 - 2015/7/20

N2 - Aire is a transcriptional regulator that induces the promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for the induction of immunological self-tolerance. Studies have offered molecular insights into how Aire operates, but more comprehensive understanding of this process still remains elusive. Here we found abundant expression of the protein deacetylase Sirtuin-1 (Sirt1) in mature Aire + mTECs, wherein it was required for the expression of Aire-dependent TRA-encoding genes and the subsequent induction of immunological self-tolerance. Our study elucidates a previously unknown molecular mechanism for Aire-mediated transcriptional regulation and identifies a unique function for Sirt1 in preventing organ-specific autoimmunity.

AB - Aire is a transcriptional regulator that induces the promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for the induction of immunological self-tolerance. Studies have offered molecular insights into how Aire operates, but more comprehensive understanding of this process still remains elusive. Here we found abundant expression of the protein deacetylase Sirtuin-1 (Sirt1) in mature Aire + mTECs, wherein it was required for the expression of Aire-dependent TRA-encoding genes and the subsequent induction of immunological self-tolerance. Our study elucidates a previously unknown molecular mechanism for Aire-mediated transcriptional regulation and identifies a unique function for Sirt1 in preventing organ-specific autoimmunity.

UR - http://www.scopus.com/inward/record.url?scp=84931432951&partnerID=8YFLogxK

U2 - 10.1038/ni.3194

DO - 10.1038/ni.3194

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 26006015

AN - SCOPUS:84931432951

SN - 1529-2908

VL - 16

SP - 737

EP - 745

JO - Nature Immunology

JF - Nature Immunology

IS - 7

ER -

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

ملخص

الوصول إلى المستند

الملفات والروابط الأخرى

بصمة

قم بذكر هذا