TY - JOUR
T1 - Skin penetration of minerals in psoriatics and guinea-pigs bathing in hypertonic salt solutions
AU - Shani, J.
AU - Barak, S.
AU - Levi, D.
AU - Ram, M.
AU - Schachner, E. R.
AU - Schlesinger, T.
AU - Robberecht, H.
AU - Van Grieken, R.
AU - Avrach, W. W.
N1 - Funding Information:
This work was supported in part by the Dead-Sea Works Ltd., Israel, by the Israeli Health Resorts Authority and by the Joint Research Fund of the Hebrew University and Hadassah. The authors acknowledge the comments of Dr. D. Albin. H. Robberecht acknowledges support from the Belgian Ministry of Health and from the Israeli-Belgian Cultural-Exchange Program.
PY - 1985/6
Y1 - 1985/6
N2 - Penetration of electrolytes through the human skin was measured in healthy volunteers and in psoriatic patients after bathing in the Dead-Sea or in simulated bath-salt solutions. Significant increases in the levels of serum Br, Rb, Ca and Zn were noticed only in the psoriatic patients after daily bathing in the Dead-Sea for a 4-week regimen. Guinea-pigs "bathed" in simulated Dead-Sea bath-salt solutions containing radionuclides of Ca, Mg, K and Br. Traces of each radionuclide were detected in the blood and in some internal organs after 60 minutes of bathing. The radionuclides showed a physiological pattern in their organ distribution. Even though the whole investigation was carried out in hypertonic solutions, there is a definite penetration of salts through healthy (human and guinea-pigs) and damaged (psoriatic) epidermis. This finding suggests that improvement of the psoriatic condition after bathing in the Dead-Sea, may be partly attributed (in addition to ultraviolet irradiation) to the minerals' effect on the psoriatic skin.
AB - Penetration of electrolytes through the human skin was measured in healthy volunteers and in psoriatic patients after bathing in the Dead-Sea or in simulated bath-salt solutions. Significant increases in the levels of serum Br, Rb, Ca and Zn were noticed only in the psoriatic patients after daily bathing in the Dead-Sea for a 4-week regimen. Guinea-pigs "bathed" in simulated Dead-Sea bath-salt solutions containing radionuclides of Ca, Mg, K and Br. Traces of each radionuclide were detected in the blood and in some internal organs after 60 minutes of bathing. The radionuclides showed a physiological pattern in their organ distribution. Even though the whole investigation was carried out in hypertonic solutions, there is a definite penetration of salts through healthy (human and guinea-pigs) and damaged (psoriatic) epidermis. This finding suggests that improvement of the psoriatic condition after bathing in the Dead-Sea, may be partly attributed (in addition to ultraviolet irradiation) to the minerals' effect on the psoriatic skin.
UR - https://www.scopus.com/pages/publications/0021876925
U2 - 10.1016/0031-6989(85)90123-7
DO - 10.1016/0031-6989(85)90123-7
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C2 - 4023031
AN - SCOPUS:0021876925
SN - 0031-6989
VL - 17
SP - 501
EP - 512
JO - Pharmacological Research Communications
JF - Pharmacological Research Communications
IS - 6
ER -