@article{2ee51ff8ff8d40ff96e784b510424ebe,
title = "SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα",
abstract = "How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.",
keywords = "PPARα, SIRT6, beta-oxidation, deacetylase, fasting, liver",
author = "Shoshana Naiman and Huynh, {Frank K.} and Reuven Gil and Yair Glick and Yael Shahar and Noga Touitou and Liat Nahum and Avivi, {Matan Y.} and Asael Roichman and Yariv Kanfi and Gertler, {Asaf A.} and Tirza Doniger and Ilkayeva, {Olga R.} and Ifat Abramovich and Orly Yaron and Batia Lerrer and Eyal Gottlieb and Harris, {Robert A.} and Doron Gerber and Hirschey, {Matthew D.} and Cohen, {Haim Y.}",
note = "Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = dec,
day = "17",
doi = "10.1016/j.celrep.2019.11.067",
language = "אנגלית",
volume = "29",
pages = "4127--4143.e8",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "12",
}