Safety of codeine during breastfeeding: Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine

Parvaz Madadi; Gideon Koren; James Cairns; David Chitayat; Andrea Gaedigk; J. Steven Leeder; Ronni Teitelbaum; Tatyana Karaskov; Katarina Aleksa

Safety of codeine during breastfeeding: Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine

Parvaz Madadi, Gideon Koren, James Cairns, David Chitayat, Andrea Gaedigk, J. Steven Leeder, Ronni Teitelbaum, Tatyana Karaskov, Katarina Aleksa

نتاج البحث: نشر في مجلة › مقالة مرجعية › مراجعة النظراء

152 اقتباسات (Scopus)

ملخص

QUESTION: Recently a newborn died from morphine poisoning when his mother used codeine while breastfeeding. Many patients receive codeine for postlabour pain. Is it safe to prescribe codeine for nursing mothers? ANSWER: When a mother is an ultrarapid metabolizer of cytochrome P450 2D6, she produces much more morphine when taking codeine than most people do. In this situation, newborns might be exposed to toxic levels of morphine when breastfeeding. Options to reduce this risk include discontinuing codeine after 2 to 3 days of use and being aware of symptoms of potential opioid toxicity in both mothers and newborns.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	33-35
عدد الصفحات	3
دورية	Canadian Family Physician
مستوى الصوت	53
رقم الإصدار	1
حالة النشر	نُشِر - يناير 2007
منشور خارجيًا	نعم

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

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title = "Safety of codeine during breastfeeding: Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine",

abstract = "QUESTION: Recently a newborn died from morphine poisoning when his mother used codeine while breastfeeding. Many patients receive codeine for postlabour pain. Is it safe to prescribe codeine for nursing mothers? ANSWER: When a mother is an ultrarapid metabolizer of cytochrome P450 2D6, she produces much more morphine when taking codeine than most people do. In this situation, newborns might be exposed to toxic levels of morphine when breastfeeding. Options to reduce this risk include discontinuing codeine after 2 to 3 days of use and being aware of symptoms of potential opioid toxicity in both mothers and newborns.",

author = "Parvaz Madadi and Gideon Koren and James Cairns and David Chitayat and Andrea Gaedigk and Leeder, {J. Steven} and Ronni Teitelbaum and Tatyana Karaskov and Katarina Aleksa",

year = "2007",

month = jan,

language = "אנגלית",

volume = "53",

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journal = "Canadian Family Physician",

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}

Safety of codeine during breastfeeding: Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine. / Madadi, Parvaz; Koren, Gideon; Cairns, James وآخرون.
في: Canadian Family Physician, المجلد 53, رقم 1, ٠١.٢٠٠٧, صفحة 33-35.

نتاج البحث: نشر في مجلة › مقالة مرجعية › مراجعة النظراء

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T2 - Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine

AU - Madadi, Parvaz

AU - Koren, Gideon

AU - Cairns, James

AU - Chitayat, David

AU - Gaedigk, Andrea

AU - Leeder, J. Steven

AU - Teitelbaum, Ronni

AU - Karaskov, Tatyana

AU - Aleksa, Katarina

PY - 2007/1

Y1 - 2007/1

N2 - QUESTION: Recently a newborn died from morphine poisoning when his mother used codeine while breastfeeding. Many patients receive codeine for postlabour pain. Is it safe to prescribe codeine for nursing mothers? ANSWER: When a mother is an ultrarapid metabolizer of cytochrome P450 2D6, she produces much more morphine when taking codeine than most people do. In this situation, newborns might be exposed to toxic levels of morphine when breastfeeding. Options to reduce this risk include discontinuing codeine after 2 to 3 days of use and being aware of symptoms of potential opioid toxicity in both mothers and newborns.

AB - QUESTION: Recently a newborn died from morphine poisoning when his mother used codeine while breastfeeding. Many patients receive codeine for postlabour pain. Is it safe to prescribe codeine for nursing mothers? ANSWER: When a mother is an ultrarapid metabolizer of cytochrome P450 2D6, she produces much more morphine when taking codeine than most people do. In this situation, newborns might be exposed to toxic levels of morphine when breastfeeding. Options to reduce this risk include discontinuing codeine after 2 to 3 days of use and being aware of symptoms of potential opioid toxicity in both mothers and newborns.

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JO - Canadian Family Physician

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Safety of codeine during breastfeeding: Fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine

ملخص

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