Proteomic analyses of transgenic LQT1 and LQT2 rabbit hearts elucidate an increase in expression and activity of energy producing enzymes

Keyphrases

• Transgenic 100%
• Rabbit Heart 100%
• Long QT Syndrome Type 2 100%
• Long QT Syndrome 100%
• Proteomic Analysis 100%
• Littermate Controls 40%
• ATP Generation 20%
• Mass Spectrometry 10%
• Protein Expression 10%
• Lamin 10%
• Transgenic Rabbit Model 10%
• Creatine Kinase 10%
• Western Blot Analysis 10%
• Lactate Dehydrogenase 10%
• Increased Demand 10%
• Enzyme Assay 10%
• Pyruvate Dehydrogenase 10%
• Failing Heart 10%
• Metabolic Pathway 10%
• Two-dimensional Difference Gel Electrophoresis 10%
• Energy Supply 10%
• Differentially Expressed Proteins 10%
• Protein Disulfide Isomerase A3 10%
• Genomic Mechanisms 10%
• Key Metabolic Enzymes 10%
• Dynamin 10%
• Very-long-chain 10%
• Quantitative Proteomics 10%
• Acyl-CoA Dehydrogenase 10%
• Fatty Acids 10%
• Desmoplakin 10%
• α-Actinin-2 10%
• Rate-limiting Enzyme 10%
• Energy Generation 10%
• Mitochondrial Function 10%
• Metabolic Remodeling 10%
• Cytochrome c Oxidase 10%
• Succinate Dehydrogenase 10%
• Mitochondrial Aldehyde Dehydrogenase 10%
• Biochemical Mechanism 10%
• I-gel 10%
• Glycogen Phosphorylase 10%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Transgenics 100%
• Leporidae 100%
• Long QT Syndrome 100%
• Proteomics 100%
• Adenosine Triphosphate 16%
• Upregulation 16%
• Downregulation 5%
• Mass Spectrometry 5%
• Protein Expression 5%
• Metabolic Pathway 5%
• Lamin 5%
• Transgenic Rabbit 5%
• Rabbit Model 5%
• Oxidoreductase 5%
• Creatine Kinase 5%
• Western Blot 5%
• Lactate Dehydrogenase 5%
• Pyruvate Dehydrogenase 5%
• Fumarate Reductase 5%
• Glycogen Phosphorylase 5%
• Cytochrome C Oxidase 5%
• Dynamin 5%
• Mitochondrial Protein 5%
• Enzyme Assay 5%
• Protein Disulfide-Isomerase 5%
• Actinin, Alpha 2 5%
• Dehydrogenase 5%
• Desmoplakin 5%
• Quantitative Proteomics 5%
• Succinate Dehydrogenase 5%
• Aldehyde Dehydrogenase 5%
• Acyl-CoA 5%
• Genomics 5%
• Gel Electrophoresis 5%