TY - JOUR
T1 - Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clones in Myeloproliferative Neoplasm Patients
T2 - A Cross-Sectional Study
AU - Gutwein, Odit
AU - Englander, Yoav
AU - Herzog-Tzarfati, Katrin
AU - Filipovich-Rimon, Talia
AU - Apel, Arie
AU - Marcus, Ronit
AU - Rahimi-Levene, Naomi
AU - Koren-Michowitz, Maya
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/12
Y1 - 2019/12
N2 - Paroxysmal nocturnal hemoglobinuria (PNH) and myeloproliferative neoplasm (MPN) are diseases associated with increased thrombosis. PNH clones are commonly found in other hematologic diseases, such as myelodysplastic syndromes and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.
AB - Paroxysmal nocturnal hemoglobinuria (PNH) and myeloproliferative neoplasm (MPN) are diseases associated with increased thrombosis. PNH clones are commonly found in other hematologic diseases, such as myelodysplastic syndromes and aplastic anemia. The presence of PNH clones was studied in consecutive MPN patients. A prevalence of 2% and an association with the JAK2 mutation was found. Presence of a PNH clone could potentially influence the clinical course of MPN.
KW - Clones
KW - JAK2 V617F
KW - MPN
KW - PNH
UR - http://www.scopus.com/inward/record.url?scp=85072999616&partnerID=8YFLogxK
U2 - 10.1016/j.clml.2019.07.441
DO - 10.1016/j.clml.2019.07.441
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C2 - 31601527
AN - SCOPUS:85072999616
SN - 2152-2650
VL - 19
SP - 812
EP - 814
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 12
ER -