Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults

Keyphrases

• 12-year-olds 20%
• Adult children 20%
• Adverse Drug Reaction 40%
• Adverse Reactions 20%
• Benznidazole 100%
• Blood Concentration 20%
• Cardiac Morbidity 20%
• Chagas Disease 40%
• Clearance Rate 20%
• Clinical Pharmacology 20%
• Drug Concentration 20%
• Older Adults 20%
• Older children 20%
• One-compartment Model 20%
• Pediatric Chagas Disease 100%
• Pediatric Pharmacotherapy 20%
• Pharmacokinetic Analysis 20%
• Pharmacokinetic Data 20%
• Pharmacokinetic Study 100%
• Plasma Concentration 100%
• Population Pharmacokinetics 100%
• Small children 20%
• Steady State 20%
• Therapeutic Response 20%
• Treatment Course 20%
• Trial Registration 20%
• Trypanosoma Cruzi (T. cruzi) 20%
• Young Patients 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Adverse Drug Reaction 40%
• Adverse Event 20%
• Benznidazole 100%
• Chagas Disease 100%
• Clinical Pharmacology 20%
• Cohort Study 20%
• Drug Concentration 20%
• Pharmacokinetics 100%
• Trypanosoma Cruzi 20%