Patrolling monocytes control tumor metastasis to the lung

Richard N. Hanna, Caglar Cekic, Duygu Sag, Robert Tacke, Graham D. Thomas, Heba Nowyhed, Erica Herrley, Nicole Rasquinha, Sara McArdle, Runpei Wu, Esther Peluso, Daniel Metzger, Hiroshi Ichinose, Iftach Shaked, Grzegorz Chodaczek, Subhra K. Biswas, Catherine C. Hedrick

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

354 اقتباسات (Scopus)

ملخص

The immune system plays an important role in regulating tumor growth and metastasis. Classical monocytes promote tumorigenesis and cancer metastasis, but how nonclassical "patrolling" monocytes (PMo) interact with tumors is unknown. Here we show that PMo are enriched in the microvasculature of the lung and reduce tumor metastasis to lung in multiple mouse metastatic tumor models. Nr4a1-deficient mice, which specifically lack PMo, showed increased lung metastasis in vivo. Transfer of Nr4a1-proficient PMo into Nr4a1-deficient mice prevented tumor invasion in the lung. PMo established early interactions with metastasizing tumor cells, scavenged tumor material from the lung vasculature, and promoted natural killer cell recruitment and activation. Thus, PMo contribute to cancer immunosurveillance and may be targets for cancer immunotherapy.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)985-990
عدد الصفحات6
دوريةScience
مستوى الصوت350
رقم الإصدار6263
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 20 نوفمبر 2015
منشور خارجيًانعم

بصمة

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