TY - JOUR
T1 - Oral nutritional supplement fortified with beta-alanine improves physical working capacity in older adults
T2 - A randomized, placebo-controlled study
AU - McCormack, William P.
AU - Stout, Jeffrey R.
AU - Emerson, Nadia S.
AU - Scanlon, Tyler C.
AU - Warren, Ashlee M.
AU - Wells, Adam J.
AU - Gonzalez, Adam M.
AU - Mangine, Gerald T.
AU - Robinson, Edward H.
AU - Fragala, Maren S.
AU - Hoffman, Jay R.
N1 - Funding Information:
We would like to thank the Learning Institute For Elders (LIFE) at the University of Central Florida for participating in this study. This study was supported by a grant from Abbott Nutrition .
PY - 2013/9
Y1 - 2013/9
N2 - This study examined the effects of an oral nutritional supplement fortified with two different doses of beta-alanine on body composition, muscle function and physical capacity in older adults. Using a double-blind placebo controlled design, 60 men and women (age±SD=70.7±6.2yrs) were randomly assigned to one of three treatment groups: 1) oral nutritional supplement (ONS; n=20) (8oz; 230kcal; 12g PRO; 31g CHO; 6g FAT), 2) ONS plus 800mg beta-alanine (ONS800; n=19), and 3) ONS plus 1200mg beta-alanine (ONS1200; n=21). Treatments were consumed twice per day for 12 weeks. At pre- and post-supplementation period, participants performed a discontinuous, submaximal cycle ergometry test to determine physical working capacity at fatigue threshold (PWCFT). Fat mass, total body and arm lean soft tissue mass (ALSTM) were measured with DEXA while muscle strength was assessed with handgrip dynamometry (GRIP) and 30-s sit-to-stand (STS) was used to measure lower body functionality. Muscle quality (MQ) was calculated with GRIPmax and DEXA derived ALSTM [GRIP (kg)·ALSTM (kg)-1]. Two-way analysis of variance was used to compare pre- to post-supplementation measures and group differences. There were 16 dropouts over the duration of the study. Final group sizes were ONS=16 (m=11, w=5), ONS800=15 (m=5, w=10), and ONS1200=13 (m=6, w=7). No significant changes were observed for body composition or GRIP values pre to post. Significant increases in PWCFT were seen in ONS1200 (13.6%) and ONS800 (17.8%) pre- to post-supplementation (p<0.05). These changes were significantly greater (p<0.05) than the changes in ONS (-6.3%). ONS1200 and ONS had significant increases in STS (22.2 and 10.7%, respectively). While ONS significantly increased in STS, no differences (p>0.05) in change scores were found between ONS and ONS800. ONS fortified with beta-alanine may improve physical working capacity, muscle quality and function in older men and women. These findings could have importance in the perception of frailty, and the maintenance of health and independent living in older adults.
AB - This study examined the effects of an oral nutritional supplement fortified with two different doses of beta-alanine on body composition, muscle function and physical capacity in older adults. Using a double-blind placebo controlled design, 60 men and women (age±SD=70.7±6.2yrs) were randomly assigned to one of three treatment groups: 1) oral nutritional supplement (ONS; n=20) (8oz; 230kcal; 12g PRO; 31g CHO; 6g FAT), 2) ONS plus 800mg beta-alanine (ONS800; n=19), and 3) ONS plus 1200mg beta-alanine (ONS1200; n=21). Treatments were consumed twice per day for 12 weeks. At pre- and post-supplementation period, participants performed a discontinuous, submaximal cycle ergometry test to determine physical working capacity at fatigue threshold (PWCFT). Fat mass, total body and arm lean soft tissue mass (ALSTM) were measured with DEXA while muscle strength was assessed with handgrip dynamometry (GRIP) and 30-s sit-to-stand (STS) was used to measure lower body functionality. Muscle quality (MQ) was calculated with GRIPmax and DEXA derived ALSTM [GRIP (kg)·ALSTM (kg)-1]. Two-way analysis of variance was used to compare pre- to post-supplementation measures and group differences. There were 16 dropouts over the duration of the study. Final group sizes were ONS=16 (m=11, w=5), ONS800=15 (m=5, w=10), and ONS1200=13 (m=6, w=7). No significant changes were observed for body composition or GRIP values pre to post. Significant increases in PWCFT were seen in ONS1200 (13.6%) and ONS800 (17.8%) pre- to post-supplementation (p<0.05). These changes were significantly greater (p<0.05) than the changes in ONS (-6.3%). ONS1200 and ONS had significant increases in STS (22.2 and 10.7%, respectively). While ONS significantly increased in STS, no differences (p>0.05) in change scores were found between ONS and ONS800. ONS fortified with beta-alanine may improve physical working capacity, muscle quality and function in older men and women. These findings could have importance in the perception of frailty, and the maintenance of health and independent living in older adults.
KW - Beta-alanine
KW - Muscle quality
KW - Older adults
KW - Oral nutritional supplement
KW - Physical working capacity
UR - https://www.scopus.com/pages/publications/84880804255
U2 - 10.1016/j.exger.2013.06.003
DO - 10.1016/j.exger.2013.06.003
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C2 - 23832078
AN - SCOPUS:84880804255
SN - 0531-5565
VL - 48
SP - 933
EP - 939
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 9
ER -