One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction

Gary Gellerman; Vladimir Gaisin; Tamara Brider

doi:10.1016/j.tetlet.2009.12.020

One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and S_NAr reaction

Gary Gellerman
, Vladimir Gaisin
, Tamara Brider

Department of Chemical Sciences

نتاج البحث: نشر في مجلة › مقالة › مراجعة النظراء

14 اقتباسات (Scopus)

ملخص

A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and S_NAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	836-839
عدد الصفحات	4
دورية	Tetrahedron Letters
مستوى الصوت	51
رقم الإصدار	5
المعرِّفات الرقمية للأشياء	https://doi.org/10.1016/j.tetlet.2009.12.020
حالة النشر	نُشِر - 3 فبراير 2010

الوصول إلى المستند

10.1016/j.tetlet.2009.12.020

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

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title = "One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction",

abstract = "A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.",

keywords = "9-Aminoacridine, Nucleophilic substitution, One-pot synthesis, Reductive alkylation",

author = "Gary Gellerman and Vladimir Gaisin and Tamara Brider",

year = "2010",

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doi = "10.1016/j.tetlet.2009.12.020",

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T1 - One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction

AU - Gellerman, Gary

AU - Gaisin, Vladimir

AU - Brider, Tamara

PY - 2010/2/3

Y1 - 2010/2/3

N2 - A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

AB - A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.

KW - 9-Aminoacridine

KW - Nucleophilic substitution

KW - One-pot synthesis

KW - Reductive alkylation

UR - https://www.scopus.com/pages/publications/73049084566

U2 - 10.1016/j.tetlet.2009.12.020

DO - 10.1016/j.tetlet.2009.12.020

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VL - 51

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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