Once-daily versus twice-daily dosing of digoxin in the pediatric age group

TY - JOUR

T1 - Once-daily versus twice-daily dosing of digoxin in the pediatric age group

AU - Zalzstein, Eli

AU - Koren, Gideon

AU - Levy, Maurice

AU - Bentur, Yedidia

AU - MacLeod, Stuart

AU - Freedom, Robert

N1 - Funding Information: Digoxin was administered for a wide spectrum of cardiac Supported in part by grant No. MA8544 from the Medical Research Council of Canada and by a grant from Burroughs Wellcome Inc. of Canada. Submitted for publication May 9, 1989; accepted July 10, 1989. Reprint requests: Gideon Koren, MD, Division of Clinical Pharmacology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario M5G 1X8, Canada. *Specialty resident of Ontario Ministry of Health. **Career Scientist of Ontario Ministry of Health. 9/26/15155 conditions: five after cardiac surgery, four prophylactically for supraventricular tachycardia; two for transposition of the great arteries and ventricular septal defect, and one for an atrioventricular septal defect. All patients were in a stable clinical condition. The mean maintenance dose was 9.1 ~zg/kg (range 5 to 11 t~g/kg). Initially, daily maintenance dosage was given every 12 hours in equal doses. Blood sampling was performed in the patient's homes by finger or heel pricks; 0.5 to 0.8 ml was drawn from each sample. Assays were done in the therapeutic drug monitoring laboratory at The Hospital for Sick Children, Toronto, by the TDX method (Abbott Ltd., Mississauga, Ontario, Canada). The coefficient of variation of this test is less than 5%. Heart rate, respiratory rate, and liver size were recorded at every visit before blood sampling was performed. In addition, the parents were asked to complete a daily diary, recording changes in the following: general health, behavior and sleeping patterns, appetite and feeding patterns, and gastrointestinal tract symptoms (anorexia, nausea, diarrhea). Parents could contact one of us, a pediatric cardiologist (E.Z.), 24 hours a day for report and consultation during the study.

PY - 1990/1

Y1 - 1990/1

UR - https://www.scopus.com/pages/publications/0025159433

U2 - 10.1016/S0022-3476(05)81665-8

DO - 10.1016/S0022-3476(05)81665-8

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C2 - 2295953

AN - SCOPUS:0025159433

SN - 0022-3476

VL - 116

SP - 137

EP - 139

JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 1

ER -