ملخص
Upon permanent stresses and in various diseases, small protein aggregates may accumulate in cells and cause toxicity. A recently discovered protective system transports these aggregates to the centrosome location via microtubules, to form a large agglomerate of aggregates called the aggresome. Here, we describe a newly developed method for isolating aggresomes. This principle can also be used for purification of other large structures and even organelles.
اللغة الأصلية | الإنجليزيّة |
---|---|
الصفحات (من إلى) | 3.38.1-3.38.9 |
دورية | Current Protocols in Cell Biology |
رقم الإصدار | SUPP.48 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | نُشِر - 2010 |
منشور خارجيًا | نعم |