Is rivastigmine safe as pretreatment against nerve agents poisoning? A pharmacological, physiological and cognitive assessment in healthy young adult volunteers

Ophir Lavon, Arik Eisenkraft, Merav Blanca, Lily Raveh, Erez Ramaty, Amir Krivoy, Jacob Atsmon, Ettie Grauer, Rachel Brandeis

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

10 اقتباسات (Scopus)

ملخص

Rivastigmine, a reversible cholinesterase inhibitor, approved as a remedy in Alzheimer's disease, was suggested as pretreatment against nerve agents poisoning. We evaluated the pharmacokinetic, pharmacodynamic, physiologic, cognitive and emotional effects of repeated rivastigmine in young healthy male adults, in a double blind, placebo controlled crossover trial. Three groups completed 3 treatment periods: 0, 1.5 and 3. mg twice a day, for a total of 5 intakes. Parameters monitored were: vital signs, ECG, laboratory tests, sialometry, visual accommodation, inspiratory peak flow, and cognitive function tests. Adverse reactions were mild. Peak blood levels and peak cholinesterase inhibition increased with repeated intakes, and high variability and non-linear pharmacokinetics were demonstrated. In addition, two cognitive functions were affected (perceptual speed and dynamic tracking). The complicated pharmacological profile and the high inter-personal variability limit the potential use of rivastigmine as pretreatment for war fighters and first responders.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)36-44
عدد الصفحات9
دوريةNeuroToxicology
مستوى الصوت49
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 1 يوليو 2015
منشور خارجيًانعم

بصمة

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