Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures

Yael Yuhas; Abraham Weizman; George P. Chrousos; Hilla Ovadia; Shai Ashkenazi

doi:10.1016/j.jneuroim.2004.04.009

Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures

Yael Yuhas
, Abraham Weizman
, George P. Chrousos
, Hilla Ovadia
, Shai Ashkenazi

نتاج البحث: نشر في مجلة › مقالة › مراجعة النظراء

11 اقتباسات (Scopus)

ملخص

Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48% vs. 28%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	36-39
عدد الصفحات	4
دورية	Journal of Neuroimmunology
مستوى الصوت	153
رقم الإصدار	1-2
المعرِّفات الرقمية للأشياء	https://doi.org/10.1016/j.jneuroim.2004.04.009
حالة النشر	نُشِر - أغسطس 2004
منشور خارجيًا	نعم

الوصول إلى المستند

10.1016/j.jneuroim.2004.04.009

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

@article{9f48bd8541af4472b12c43c07d622c91,

title = "Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures",

abstract = "Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48\% vs. 28\%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.",

keywords = "Children, Cortricotropin-releasing hormone (CRH), Seizures, Shigella",

author = "Yael Yuhas and Abraham Weizman and Chrousos, \{George P.\} and Hilla Ovadia and Shai Ashkenazi",

note = "Funding Information: This work was supported by the Wasserman Research Foundation, Tel Aviv University Medical School.",

year = "2004",

month = aug,

doi = "10.1016/j.jneuroim.2004.04.009",

language = "אנגלית",

volume = "153",

pages = "36--39",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures

AU - Yuhas, Yael

AU - Weizman, Abraham

AU - Chrousos, George P.

AU - Ovadia, Hilla

AU - Ashkenazi, Shai

N1 - Funding Information: This work was supported by the Wasserman Research Foundation, Tel Aviv University Medical School.

PY - 2004/8

Y1 - 2004/8

N2 - Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48% vs. 28%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.

AB - Convulsions are common complications of shigellosis in children. Corticotropin-releasing hormone (CRH), a stress neurohormone, has been implicated in the susceptibility of young children to seizures. We investigated the role of CRH in Shigella-related seizures. Pretreatment with Shigella dysenteriae sonicate enhanced mice response to pentylenetetrazole (PTZ)-induced seizures. Preinjection of antalarmin, a CRH-receptor 1 antagonist, decreased both the mean convulsion score (MCS: 1.6 vs. 1.1, p<0.05) and the percent of mice having seizures (48% vs. 28%, p=0.03). This indicates that CRH plays a role in the increased susceptibility to seizures following exposure to S. dysenteriae.

KW - Children

KW - Cortricotropin-releasing hormone (CRH)

KW - Seizures

KW - Shigella

UR - https://www.scopus.com/pages/publications/3242730212

U2 - 10.1016/j.jneuroim.2004.04.009

DO - 10.1016/j.jneuroim.2004.04.009

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C2 - 15265661

AN - SCOPUS:3242730212

SN - 0165-5728

VL - 153

SP - 36

EP - 39

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Involvement of the neuropeptide corticotropin-releasing hormone in an animal model of Shigella-related seizures

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