TY - JOUR
T1 - Influence of pneumococcal vaccines and respiratory syncytial virus on alveolar pneumonia, Israel
AU - Weinberger, Daniel M.
AU - Givon-Lavi, Noga
AU - Shemer-Avni, Yonat
AU - Bar-Ziv, Jacob
AU - Alonso, Wladimir J.
AU - Greenberg, David
AU - Dagan, Ron
PY - 2013/7
Y1 - 2013/7
N2 - Postlicensure surveillance of pneumonia incidence can be used to estimate whether pneumococcal conjugate vaccines (PCVs) affect incidenceWe used Poisson regression models that control for baseline seasonality to determine the impact of PCVs and the possible effects of variations in virus activity in Israel on these surveillance estimatesPCV was associated with significant declines in radiologically confirmed alveolar pneumonia (RCAP) among patients <6 months, 6-17 months, and 18-35 months of age (-31% [95% CI-51% to-15%],-41% [95% CI-52 to-32%], and-34% [95% CI-42% to-25%], respectively)Respiratory syncytial virus (RSV) activity was associated with strong increases in RCAP incidence, with up to 44% of cases attributable to RSV among infants <6 months of age and lower but significant impacts in older childrenSeasonal variations, particularly in RSV activity, masked the impact of 7-valent PCVs, especially for young children in the first 2 years after vaccine introduction.
AB - Postlicensure surveillance of pneumonia incidence can be used to estimate whether pneumococcal conjugate vaccines (PCVs) affect incidenceWe used Poisson regression models that control for baseline seasonality to determine the impact of PCVs and the possible effects of variations in virus activity in Israel on these surveillance estimatesPCV was associated with significant declines in radiologically confirmed alveolar pneumonia (RCAP) among patients <6 months, 6-17 months, and 18-35 months of age (-31% [95% CI-51% to-15%],-41% [95% CI-52 to-32%], and-34% [95% CI-42% to-25%], respectively)Respiratory syncytial virus (RSV) activity was associated with strong increases in RCAP incidence, with up to 44% of cases attributable to RSV among infants <6 months of age and lower but significant impacts in older childrenSeasonal variations, particularly in RSV activity, masked the impact of 7-valent PCVs, especially for young children in the first 2 years after vaccine introduction.
UR - https://www.scopus.com/pages/publications/84879136663
U2 - 10.3201/eid1907.121625
DO - 10.3201/eid1907.121625
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 23763864
AN - SCOPUS:84879136663
SN - 1080-6040
VL - 19
SP - 1084
EP - 1091
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 7
ER -