ملخص
Indium trichloride catalyzes the reaction of vinyl azides with unfunctionalized indoles to give vinyl indoles. This is the first example of displacement of the azide group by a carbon nucleophile while preserving the vinyl function. The protocol employs very mild reaction conditions and offers excellent yields of diverse 3-vinyl indoles. It is amenable to gram scale. Access to a library of 3,3′-bis(indolyl)methanes through condensation of vinyl azides with 2 equiv of an indole is demonstrated.
اللغة الأصلية | الإنجليزيّة |
---|---|
الصفحات (من إلى) | 3759-3764 |
عدد الصفحات | 6 |
دورية | Organic Letters |
مستوى الصوت | 22 |
رقم الإصدار | 10 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | نُشِر - 15 مايو 2020 |