Increased plasma cell-free DNA is associated with low pregnancy rates among women undergoing IVF-embryo transfer

Johanna Czamanski-Cohen, Orly Sarid, Julie Cwikel, Eitan Lunenfeld, Amos Douvdevani, Eliahu Levitas, Iris Har-Vardi

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

22 اقتباسات (Scopus)

ملخص

This prospective repeated measures study was designed to examine the cell-free DNA (cfDNA) concentrations during ovarian stimulation and the relationship between cfDNA concentration and pregnancy rates in women undergoing IVF-embryo transfer. The study examined 37 women undergoing IVF treatment in an IVF unit in a university medical centre in southern Israel. cfDNA concentrations were measured by a direct fluorescence assay, pregnancy rates were identified by plasma b human chorionic gonadotrophin (HCG) concentrations and verified by vaginal ultrasound to determine gestational sac and fetal heart beats. Throughout the IVF cycle, at the three time points measured, the mean concentration of plasma cfDNA among all participants did not statistically significantly change. However, on the day of bHCG test in patients undergoing IVF-embryo transfer, plasma cfDNA concentrations were statistically significantly higher among women who did not conceive in comparison to those who conceived. Plasma cfDNA may reflect the presence of factors which interfere with embryo implantation. Further research is required to determine the usefulness of cfDNA as a biomarker of IVF outcome and to examine the underlying pathologies as potential sources for increased plasma cfDNA concentrations.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)36-41
عدد الصفحات6
دوريةReproductive BioMedicine Online
مستوى الصوت26
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - يناير 2013
منشور خارجيًانعم

بصمة

أدرس بدقة موضوعات البحث “Increased plasma cell-free DNA is associated with low pregnancy rates among women undergoing IVF-embryo transfer'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا