TY - JOUR
T1 - Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals
AU - Moussaieff, Arieh
AU - Gross, Moshe
AU - Nesher, Elimelech
AU - Tikhonov, Tatiana
AU - Yadid, Gal
AU - Pinhasov, Albert
N1 - Funding Information:
This work was supported by the Israel Ministry of Science and Technology.
PY - 2012/12
Y1 - 2012/12
N2 - Incensole acetate (IA), a constituent of Boswellia resin ('frankincense'), was previously demonstrated to exhibit an antidepressive-like effect in the Forced Swim Test (FST) in mice following single dose administration (50 mg/kg). Here, we show that acute administration of considerably lower dose (10 mg/kg) IA to selectively bred mice, showing prominent submissive behavior, exerted significant antidepressant-like effects in the FST. Furthermore, chronic administration of 1 or 5 mg/kg per day of IA for three consecutive weeks dose- and time-dependently reduced the submissiveness of the mice in the Dominant-Submissive Relationship test, developed to screen the chronic effect of antidepressants. This behavioral effect was concomitant to reduced serum corticosterone levels, dose-dependent down-regulation of corticotropin releasing factor and up-regulation of brain derived neurotrophic factor transcripts IV and VI expression in the hippocampus. These data suggest that IA modulates the hypothalamic-pituitary-adrenal (HPA) axis and influences hippocampal gene expression, leading to beneficial behavioral effects supporting its potential as a novel treatment of depressive-like disorders.
AB - Incensole acetate (IA), a constituent of Boswellia resin ('frankincense'), was previously demonstrated to exhibit an antidepressive-like effect in the Forced Swim Test (FST) in mice following single dose administration (50 mg/kg). Here, we show that acute administration of considerably lower dose (10 mg/kg) IA to selectively bred mice, showing prominent submissive behavior, exerted significant antidepressant-like effects in the FST. Furthermore, chronic administration of 1 or 5 mg/kg per day of IA for three consecutive weeks dose- and time-dependently reduced the submissiveness of the mice in the Dominant-Submissive Relationship test, developed to screen the chronic effect of antidepressants. This behavioral effect was concomitant to reduced serum corticosterone levels, dose-dependent down-regulation of corticotropin releasing factor and up-regulation of brain derived neurotrophic factor transcripts IV and VI expression in the hippocampus. These data suggest that IA modulates the hypothalamic-pituitary-adrenal (HPA) axis and influences hippocampal gene expression, leading to beneficial behavioral effects supporting its potential as a novel treatment of depressive-like disorders.
KW - Incensole acetate
KW - brain derived neurotrophic factor (BDNF)
KW - corticosterone
KW - corticotrophin releasing factor (CRF)
KW - depression
KW - dominant-submissive relationship (DSR)
UR - http://www.scopus.com/inward/record.url?scp=84870467267&partnerID=8YFLogxK
U2 - 10.1177/0269881112458729
DO - 10.1177/0269881112458729
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 23015543
AN - SCOPUS:84870467267
SN - 0269-8811
VL - 26
SP - 1584
EP - 1593
JO - Journal of Psychopharmacology
JF - Journal of Psychopharmacology
IS - 12
ER -