Improved antimicrobial peptides based on acyl-lysine oligomers

Inna S. Radzishevsky; Shahar Rotem; Dmitry Bourdetsky; Shiri Navon-Venezia; Yehuda Carmeli; Amram Mor

doi:10.1038/nbt1309

Improved antimicrobial peptides based on acyl-lysine oligomers

Inna S. Radzishevsky
, Shahar Rotem
, Dmitry Bourdetsky
, Shiri Navon-Venezia
, Yehuda Carmeli
, Amram Mor

نتاج البحث: نشر في مجلة › مقالة › مراجعة النظراء

246 اقتباسات (Scopus)

ملخص

We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	657-659
عدد الصفحات	3
دورية	Nature Biotechnology
مستوى الصوت	25
رقم الإصدار	6
المعرِّفات الرقمية للأشياء	https://doi.org/10.1038/nbt1309
حالة النشر	نُشِر - يونيو 2007
منشور خارجيًا	نعم

الوصول إلى المستند

10.1038/nbt1309

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

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title = "Improved antimicrobial peptides based on acyl-lysine oligomers",

abstract = "We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.",

author = "Radzishevsky, \{Inna S.\} and Shahar Rotem and Dmitry Bourdetsky and Shiri Navon-Venezia and Yehuda Carmeli and Amram Mor",

note = "Funding Information: This work was supported by The Israel Science Foundation (grant no. 387/03) and by BiolineRx (grant no. 2006992).",

year = "2007",

month = jun,

doi = "10.1038/nbt1309",

language = "אנגלית",

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journal = "Nature Biotechnology",

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TY - JOUR

T1 - Improved antimicrobial peptides based on acyl-lysine oligomers

AU - Radzishevsky, Inna S.

AU - Rotem, Shahar

AU - Bourdetsky, Dmitry

AU - Navon-Venezia, Shiri

AU - Carmeli, Yehuda

AU - Mor, Amram

N1 - Funding Information: This work was supported by The Israel Science Foundation (grant no. 387/03) and by BiolineRx (grant no. 2006992).

PY - 2007/6

Y1 - 2007/6

N2 - We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

AB - We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

UR - https://www.scopus.com/pages/publications/34250157753

U2 - 10.1038/nbt1309

DO - 10.1038/nbt1309

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C2 - 17529972

AN - SCOPUS:34250157753

SN - 1087-0156

VL - 25

SP - 657

EP - 659

JO - Nature Biotechnology

JF - Nature Biotechnology

IS - 6

ER -

Improved antimicrobial peptides based on acyl-lysine oligomers

ملخص

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الملفات والروابط الأخرى

بصمة

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