Implementation of a six-around-one optical probe based on diffuse light spectroscopy for study of cerebral properties in a murine mouse model of autism spectrum disorder

Andrew Kozhuhov, Matanel Tfilin, Gadi Turgeman, Asher Ornoy, Joseph Yanai, David Abookasis

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

4 اقتباسات (Scopus)

ملخص

Light reflectance spectroscopy (LRS) is a multispectral technique, sensitive to the absorption and scattering properties of biological molecules in tissues. It is used as a noninvasive tool to extract quantitative physiological information from human tissues and organs. A near-infrared LRS based on a single optical probe was used to monitor changes in optical and hemodynamic parameters in a mouse model of autism. A murine model of autism induced by developmental exposure to valproic acid (VPA) was used. Since autism could be attributed to neuroanatomical changes, we hypothesize that these changes can be detected using the LRS because spectral properties depend on both molecular composition and structural changes. The fiber-optic probe in the setup consisted of seven small optical fibers: six fibers for illumination placed in a circular manner around a central single collection fiber. Overall, measurements demonstrate changes in diffused reflectance spectra, cerebral optical tissue properties (absorption and scattering), and chromophore levels. Furthermore, we were able to identify differences between male and female groups. Finally, the effectiveness of S-Adenosylmethionine as a drug therapy was studied and found to improve the hemodynamic outcome. For the first time, to the best of our knowledge, the LRS is utilized to study variations in brain parameters in the VPA autism model mice through an intact scalp.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)6809-6816
عدد الصفحات8
دوريةApplied Optics
مستوى الصوت59
رقم الإصدار23
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 10 أغسطس 2020

بصمة

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