Free radicals induced peptide damage in the presence of transition metal ions: A plausible pathway for biological deleterious processes

Sara Goldstein, Gidon Czapski, Haim Cohen, Dan Meyerstein

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

18 اقتباسات (Scopus)

ملخص

When aqueons N2O-saturated solutions containing glycine-N-tert-butylamide (L) and Cr2+(aq) or Cu+(aq) are irradiated, transients with metal-carbon σ-bonds are formed with rate constants of (4.4 ± 0.5) × 107 and (5.2 ± 0.3) × 109 M- s-, respectively. In the chromium(II) system, after a fast process (k = 43 ± 4 s-1), possibly chelaton, the transient decomposes verly slowly (k = 0.003 ± 0.001 h-1) via a β-elimination process to yield 2-methylpropene and glycinamide, i.e., a cleavage of the peptide bond takes place. However, in the copper(I) system the heterolytic cleavage of the σ-bond and the reaction of the transient complex with L-Cu2+ compete efficiently with the β-elimination process. The latter reaction leads to some modification of the amide. We suggest that the formation and decomposition od transients with metal-carbon σ-bonds may be describe an additional pathway for peptide damage induced by alipathic free radical precursors (e.g., OH., H2O2) in the presence of transition metal ions.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)11-18
عدد الصفحات8
دوريةFree Radical Biology and Medicine
مستوى الصوت17
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - يوليو 1994
منشور خارجيًانعم

بصمة

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