TY - JOUR
T1 - Fetal distribution of cocaine
T2 - Case analysis
AU - Klein, J.
AU - Greenwald, M.
AU - Becker, L.
AU - Koren, G.
N1 - Funding Information:
Dr. Koren is a Career Scientist of Ontario Ministry of Health. Supported by grants from PSI, Toronto, Medical Research Council of Canada, and Health and Welfare, Canada. Address reprint requests to Gideon Koren, M.D., The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1x8 Canada.
PY - 1992
Y1 - 1992
N2 - The implications of gestational cocaine use are widely documented. There is evidence that cocaine crosses the placenta in animals and humans; however, the fetal distribution of the drug and its metabolites has not been documented. We describe the distribution of cocaine and benzoylecgonine (BE) in the fetus of a cocaine user mother. Cocaine and BE were detected in brain, scalp, liver, kidney, heart, placenta, blood, and hair. The liver contained substantially more cocaine than other tissues, whereas the brain had more BE than any other sample..
AB - The implications of gestational cocaine use are widely documented. There is evidence that cocaine crosses the placenta in animals and humans; however, the fetal distribution of the drug and its metabolites has not been documented. We describe the distribution of cocaine and benzoylecgonine (BE) in the fetus of a cocaine user mother. Cocaine and BE were detected in brain, scalp, liver, kidney, heart, placenta, blood, and hair. The liver contained substantially more cocaine than other tissues, whereas the brain had more BE than any other sample..
KW - Benzoylecgonine
KW - Cocaine
KW - Fetus
KW - Radioimmunoassay
UR - http://www.scopus.com/inward/record.url?scp=0026711224&partnerID=8YFLogxK
U2 - 10.3109/15513819209023326
DO - 10.3109/15513819209023326
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C2 - 1409144
AN - SCOPUS:0026711224
SN - 1551-3815
VL - 12
SP - 463
EP - 468
JO - Fetal and Pediatric Pathology
JF - Fetal and Pediatric Pathology
IS - 3
ER -