Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Boris Redko; Amnon Albeck; Gary Gellerman

doi:10.1039/c2nj40567a

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

Boris Redko
, Amnon Albeck
, Gary Gellerman

Department of Chemical Sciences

نتاج البحث: نشر في مجلة › مقالة › مراجعة النظراء

9 اقتباسات (Scopus)

ملخص

A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH₄ reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC₅₀ values.

اللغة الأصلية	الإنجليزيّة
الصفحات (من إلى)	2188-2191
عدد الصفحات	4
دورية	New Journal of Chemistry
مستوى الصوت	36
رقم الإصدار	11
المعرِّفات الرقمية للأشياء	https://doi.org/10.1039/c2nj40567a
حالة النشر	نُشِر - نوفمبر 2012

الوصول إلى المستند

10.1039/c2nj40567a

الملفات والروابط الأخرى

Link to publication in Scopus

قم بذكر هذا

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title = "Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs",

abstract = "A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.",

author = "Boris Redko and Amnon Albeck and Gary Gellerman",

year = "2012",

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doi = "10.1039/c2nj40567a",

language = "אנגלית",

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journal = "New Journal of Chemistry",

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T1 - Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

AU - Redko, Boris

AU - Albeck, Amnon

AU - Gellerman, Gary

PY - 2012/11

Y1 - 2012/11

N2 - A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.

AB - A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values.

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DO - 10.1039/c2nj40567a

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AN - SCOPUS:84867545816

SN - 1144-0546

VL - 36

SP - 2188

EP - 2191

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 11

ER -

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

ملخص

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الملفات والروابط الأخرى

بصمة

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