Efficacy and tolerability of sodium picosulphate with magnesium citrate versus polyethylene glycol electrolyte lavage solution for colouoscopy preparation

A. Regev, G. Fraser, G. Delpre, A. Laiser, A. Neeman, E. Maoz, V. Anikin, Y. Niv

نتاج البحث: نشر في مجلةمقالةمراجعة النظراء

1 اقتباس (Scopus)

ملخص

We compared a colonic preparation with sodium picosulphate and magnesium citrate (SPS-Mg) to a polyethylene glycol electrolyte lavage (PEG-EL) solution for quality of bowel cleansing, patient discomfort and side effects. Methods: Sixty-eight consecutive patients were randomly assigned to preparation with 3 sachets of SPS-Mg (16.5 gr each) (n=39) or 3 liters of PEG-EL (n=29) on the day before colonoscopy. Shortly before the procedure, each patient was interviewed to determine the degree of discomfort (from 1 = none or mild to 4 = excellent), and the extent of colonoscopy was noted. Results: The 2 groups were similar in patient age, gender and origin, and indication for colonoscopy. Of the 29 PEG-EL patients, 4 (14%) did not complete the preparation because of side effects (nausea, vomiting and palpitations). The degree of discomfort was significantly greater with PEG-EL (mean score 2.3±0.7) than with SPS-Mg (mean score, 1.4±0.5) (P<0.01). Side effects were significantly more common in the PEG-EL group (41% vs. 26%, P<0.01). Using intention-to-treat analysis, bowel cleansing proved to be significantly better with SPS-Mg than with PEG-EL (mean scores±SD, 3.05±0.9 and 2.57±1.0, respectively, P<0.05). No significant difference was noted in the extent of colonoscopy between the 2 groups (the cecum was reached in 90% of the patients in both). Conclusions: Colonic preparation with SPS-Mg is better tolerated, associated with significantly fewer side effects and results in higher quality bowel cleansing than preparation with PEG-EL.

اللغة الأصليةالإنجليزيّة
الصفحات (من إلى)320
عدد الصفحات1
دوريةGastrointestinal Endoscopy
مستوى الصوت43
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرنُشِر - 1996

بصمة

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