ملخص
Objectives: To study the effect of extracorporeal membrane oxygenation (ECMO) on the pharmacokinetics of morphine in infants. Design: A prospective, comparative study of morphine pharmacokinetics during and after ECMO. Setting: The pediatric intensive care unit at a children's hospital. Patients: Seven infants, aged 1 day to 12 months, requiring ECMO. Intervention: Infusion of morphine. Measurement and Main Results: Steady- state concentrations of morphine were used to generate a morphine clearance rate. Plasma clearance rate of morphine increased from 0.574 ± 0.3 L/kg/hr to 1.058 ± 0.727 L/kg/hr after discontinuation of ECMO (p < .01). Two infants experienced a clinical picture consistent with opioid withdrawal. Conclusion: Infants requiring morphine after ECMO may require higher dose rates to maintain adequate sedation.
| اللغة الأصلية | الإنجليزيّة |
|---|---|
| الصفحات (من إلى) | 1099-1101 |
| عدد الصفحات | 3 |
| دورية | Critical Care Medicine |
| مستوى الصوت | 22 |
| رقم الإصدار | 7 |
| المعرِّفات الرقمية للأشياء | |
| حالة النشر | نُشِر - 1994 |
| منشور خارجيًا | نعم |