TY - JOUR
T1 - Effect of neonatal circumcision on pain responses during vaccination in boys
AU - Taddio, A.
AU - Goldbach, M.
AU - Ipp, M.
AU - Stevens, B.
AU - Koren, G.
N1 - Funding Information:
Participants in the study group: S Bresciani, M G Marin, D Padula, A Rodella (Brescia); I Bulgarelli, F Chiodo, E Magliano, G Miotto, M L Muggiasca, E Pilloton, R Pozzoli, F Pregliasco, L Romano, C Stringhi (Milan); F D’Agostino, F Paolillo (Lodi); and B Zapparoli (Monza). This work was supported in part by a grant from the Italian Ministry of Health, Centro Studi, Rome. We thank Dr L Stuyver for supplying part of the reagents for genotyping.
PY - 1995/2/4
Y1 - 1995/2/4
N2 - Using data from one of our randomised trials, we investigated post-hoc whether male neonatal circumcision is associated with a greater pain response to routine vaccination at 4 or 6 months. Pain response during routine vaccination with diphtheria-pertussis-tetanus (DPT) alone or DPT followed by Haemophilus influenzae type b conjugate (HIB) was scored blind. 42 boys received DPT and 18 also received HIB. After DPT, median visual analogue scores by an observer were higher in the circumcised group (40 vs 26 mm, p=0·03) After HIB, circumcised infants had higher behavioural pain scores (8 vs 6, p=0·01) and cried longer (53 vs 19 s, p=0·02). Thus neonatal circumcision may affect pain response several months after the event.
AB - Using data from one of our randomised trials, we investigated post-hoc whether male neonatal circumcision is associated with a greater pain response to routine vaccination at 4 or 6 months. Pain response during routine vaccination with diphtheria-pertussis-tetanus (DPT) alone or DPT followed by Haemophilus influenzae type b conjugate (HIB) was scored blind. 42 boys received DPT and 18 also received HIB. After DPT, median visual analogue scores by an observer were higher in the circumcised group (40 vs 26 mm, p=0·03) After HIB, circumcised infants had higher behavioural pain scores (8 vs 6, p=0·01) and cried longer (53 vs 19 s, p=0·02). Thus neonatal circumcision may affect pain response several months after the event.
UR - https://www.scopus.com/pages/publications/0028815931
U2 - 10.1016/S0140-6736(95)90278-3
DO - 10.1016/S0140-6736(95)90278-3
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C2 - 7837863
AN - SCOPUS:0028815931
SN - 0140-6736
VL - 345
SP - 291
EP - 292
JO - The Lancet
JF - The Lancet
IS - 8945
ER -